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    NOTCH4 notch receptor 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 536128, updated on 1-Jan-2025

    Summary

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    Official Symbol
    NOTCH4provided by VGNC
    Official Full Name
    notch receptor 4provided by VGNC
    Primary source
    VGNC:VGNC:32179
    See related
    Ensembl:ENSBTAG00000025424
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NOTCH4 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (27171379..27196526)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain-containing family A member 1-like Neighboring gene butyrophilin subfamily 1 member A1 Neighboring gene butyrophilin-like protein 1 Neighboring gene PBX homeobox 2 Neighboring gene advanced glycosylation end-product specific receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Notch binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurogenic locus notch homolog protein 4
    Names
    Notch homolog 4
    notch 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206948.2 → NP_001193877.2  neurogenic locus notch homolog protein 4 precursor

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000023
      UniProtKB/TrEMBL
      A0AAA9SIR7, G3X812
      Related
      ENSBTAP00000046844.3, ENSBTAT00000050083.4
      Conserved Domains (8) summary
      smart00004
      Location:1204 → 1242
      NL; Domain found in Notch and Lin-12
      cd00054
      Location:548 → 584
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00204
      Location:1655 → 1781
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:1628 → 1658
      ANK; ANK repeat [structural motif]
      pfam00066
      Location:1254 → 1282
      Notch; LNR domain
      pfam06816
      Location:1293 → 1338
      NOD; NOTCH protein
      pfam07684
      Location:1376 → 1416
      NODP; NOTCH protein
      cl08044
      Location:1895 → 1986
      Cse1_I-E; CRISPR/Cas system-associated protein Cse1

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27171379..27196526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024983664.2 → XP_024839432.1  neurogenic locus notch homolog protein 4 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SIR7
      Related
      ENSBTAP00000082436.1, ENSBTAT00000112270.1
      Conserved Domains (8) summary
      smart00004
      Location:1204 → 1242
      NL; Domain found in Notch and Lin-12
      cd00054
      Location:548 → 584
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00204
      Location:1658 → 1784
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:1631 → 1661
      ANK; ANK repeat [structural motif]
      pfam00066
      Location:1254 → 1282
      Notch; LNR domain
      pfam06816
      Location:1293 → 1338
      NOD; NOTCH protein
      pfam07684
      Location:1376 → 1416
      NODP; NOTCH protein
      cl08044
      Location:1898 → 1989
      Cse1_I-E; CRISPR/Cas system-associated protein Cse1
    Nucleotide Protein Strain
    Heading Accession and Version

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