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    CTSD cathepsin D [ Bos taurus (domestic cattle) ]

    Gene ID: 282883, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CTSDprovided by VGNC
    Official Full Name
    cathepsin Dprovided by VGNC
    Primary source
    VGNC:VGNC:103056
    See related
    BGD:BT11600; Ensembl:ENSBTAG00000007622
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CATD
    Orthologs
    human mouse all
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    Genomic context

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    See CTSD in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (49712746..49722179)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene troponin I2, fast skeletal type Neighboring gene synaptotagmin 8 Neighboring gene interferon induced transmembrane protein 10 Neighboring gene uncharacterized LOC132344218

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Procathepsin D cannot autoactivate to cathepsin D at acid pH. Larsen LB, et al. FEBS Lett, 1993 Mar 15. PMID 8454061
    2. A novel function by cathepsin D in degradation of nucleic acids. Zhang Y, et al. Biochem Biophys Res Commun, 2023 Nov 19. PMID 37826948
    3. A novel approach for characterization of cathepsin D protease and its effect on tau and β-amyloid proteins. Malik M, et al. Neurochem Res, 2011 May. PMID 21267651
    4. Two crystal structures for cathepsin D: the lysosomal targeting signal and active site. Metcalf P, et al. EMBO J, 1993 Apr. PMID 8467789, Free PMC Article
    5. Association of polymorphisms in calpain 1, (mu/I) large subunit, calpastatin, and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle. Ribeca C, et al. Anim Genet, 2013 Apr. PMID 22548449

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel function by cathepsin D in degradation of nucleic acids.
      Title: A novel function by cathepsin D in degradation of nucleic acids.
    2. Association of polymorphisms in calpain 1, (mu/I) large subunit, calpastatin, and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle.
      Title: Association of polymorphisms in calpain 1, (mu/I) large subunit, calpastatin, and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle.
    3. findings strongly suggest a link between the lysosomal dysfunction of cathepsin D and the etiology of Alzheimer's disease
      Title: A novel approach for characterization of cathepsin D protease and its effect on tau and β-amyloid proteins.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cathepsin D
    Names
    lysosomal aspartyl protease
    NP_001159993.1
    XP_005227352.1
    XP_005227353.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166521.2 → NP_001159993.1  cathepsin D precursor

      See identical proteins and their annotated locations for NP_001159993.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000029
      UniProtKB/Swiss-Prot
      P80209, Q9TS27
      UniProtKB/TrEMBL
      Q9BGU5
      Conserved Domains (3) summary
      cd05490
      Location:75 → 406
      Cathepsin_D2; Cathepsin_D2, pepsin family of proteinases
      pfam00026
      Location:79 → 407
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:23 → 40
      A1_Propeptide; A1 Propeptide

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      49712746..49722179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005227295.5 → XP_005227352.1  cathepsin D isoform X1

      UniProtKB/Swiss-Prot
      P80209, Q9TS27
      UniProtKB/TrEMBL
      F1MMR6, Q9BGU5
      Related
      ENSBTAP00000010022.6, ENSBTAT00000010022.7
      Conserved Domains (3) summary
      cd05490
      Location:75 → 460
      Cathepsin_D2; Cathepsin_D2, pepsin family of proteinases
      pfam00026
      Location:80 → 461
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:23 → 40
      A1_Propeptide; A1 Propeptide

    2. XM_005227296.4 → XP_005227353.1  cathepsin D isoform X2

      UniProtKB/Swiss-Prot
      P80209, Q9TS27
      UniProtKB/TrEMBL
      Q9BGU5
      Related
      ENSBTAP00000068277.1, ENSBTAT00000083008.2
      Conserved Domains (3) summary
      cd05490
      Location:75 → 408
      Cathepsin_D2; Cathepsin_D2, pepsin family of proteinases
      pfam00026
      Location:80 → 409
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:23 → 40
      A1_Propeptide; A1 Propeptide
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P80209.2 GenPept UniProtKB/Swiss-Prot:P80209

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.