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    PTPN3 protein tyrosine phosphatase non-receptor type 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 511010, updated on 27-Dec-2024

    Summary

    Official Symbol
    PTPN3provided by VGNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 3provided by VGNC
    Primary source
    VGNC:VGNC:33538
    See related
    BGD:BT13701; Ensembl:ENSBTAG00000018841
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PTPN3 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (98925058..99092480, complement)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene ferric chelate reductase 1 like Neighboring gene erythrocyte membrane protein band 4.1 like 4B Neighboring gene uncharacterized LOC112447939 Neighboring gene uncharacterized LOC132346005 Neighboring gene surfeit locus protein 6-like

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Expression

    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 3
    NP_001192616.1
    XP_005210556.1
    XP_010806534.2
    XP_024851368.1
    XP_059745007.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205687.2NP_001192616.1  tyrosine-protein phosphatase non-receptor type 3

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000008
      UniProtKB/TrEMBL
      A0AAA9TDM6, E1BIH4
      Related
      ENSBTAP00000025085.7, ENSBTAT00000025085.7
      Conserved Domains (4) summary
      smart00295
      Location:31222
      B41; Band 4.1 homologues
      cd00047
      Location:671898
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:507594
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216309
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      98925058..99092480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010808232.4XP_010806534.2  tyrosine-protein phosphatase non-receptor type 3 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1LMJ6
      Conserved Domains (7) summary
      smart00194
      Location:702953
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:53244
      B41; Band 4.1 homologues
      cd00047
      Location:725952
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:561648
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:238331
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00373
      Location:137244
      FERM_M; FERM central domain
      pfam09379
      Location:55118
      FERM_N; FERM N-terminal domain
    2. XM_024995600.2XP_024851368.1  tyrosine-protein phosphatase non-receptor type 3 isoform X3

      UniProtKB/TrEMBL
      A0AAA9TDM6, E1BIH4
      Related
      ENSBTAP00000093948.1, ENSBTAT00000133595.1
      Conserved Domains (4) summary
      smart00295
      Location:31222
      B41; Band 4.1 homologues
      cd00047
      Location:671898
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:507594
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216309
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    3. XM_059889024.1XP_059745007.1  tyrosine-protein phosphatase non-receptor type 3 isoform X2

      UniProtKB/TrEMBL
      A0AAA9TDM6
    4. XM_005210499.5XP_005210556.1  tyrosine-protein phosphatase non-receptor type 3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TDM6
      Related
      ENSBTAP00000079297.1, ENSBTAT00000110981.1
      Conserved Domains (4) summary
      smart00295
      Location:31222
      B41; Band 4.1 homologues
      cd00047
      Location:703930
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:539626
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216309
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)