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    PACSIN2 protein kinase C and casein kinase substrate in neurons 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 540107, updated on 30-Jan-2025

    Summary

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    Official Symbol
    PACSIN2provided by VGNC
    Official Full Name
    protein kinase C and casein kinase substrate in neurons 2provided by VGNC
    Primary source
    VGNC:VGNC:32543
    See related
    BGD:BT25667; EnsemblRapid:ENSBTAG00070008160
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PACSIN2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (113686867..113804090, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor GTPase activating protein 3 Neighboring gene histone deacetylase complex subunit SAP18 pseudogene Neighboring gene transfer RNA glycine (anticodon GCC) Neighboring gene uncharacterized LOC101904078

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC137898

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in caveola assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in plasma membrane tubulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein kinase C and casein kinase substrate in neurons protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046468.1 → NP_001039933.1  protein kinase C and casein kinase substrate in neurons protein 2

      See identical proteins and their annotated locations for NP_001039933.1

      Status: PROVISIONAL

      Source sequence(s)
      BC114745
      UniProtKB/TrEMBL
      Q1RMR9
      Related
      ENSBTAP00070010765.1, ENSBTAT00070018388.1
      Conserved Domains (3) summary
      cd07679
      Location:18 → 275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:429 → 484
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:333 → 428
      NPF; Rabosyn-5 repeating NPF sequence-motif

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      113686867..113804090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024992038.2 → XP_024847806.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      Conserved Domains (3) summary
      cd11998
      Location:388 → 443
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:292 → 387
      NPF; Rabosyn-5 repeating NPF sequence-motif
      cl12013
      Location:1 → 234
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_005207423.5 → XP_005207480.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1LY20
      Related
      ENSBTAP00070010779.1, ENSBTAT00070018406.1
      Conserved Domains (2) summary
      cd07679
      Location:18 → 275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:388 → 443
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

    3. XM_059886641.1 → XP_059742624.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X2

      UniProtKB/TrEMBL
      Q1RMR9

    4. XM_024992037.2 → XP_024847805.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X2

      UniProtKB/TrEMBL
      Q1RMR9
      Conserved Domains (3) summary
      cd07679
      Location:18 → 275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:429 → 484
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:333 → 428
      NPF; Rabosyn-5 repeating NPF sequence-motif

    5. XM_059886642.1 → XP_059742625.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X3

    6. XM_059886640.1 → XP_059742623.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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