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    SHARPIN SHANK associated RH domain interactor [ Bos taurus (domestic cattle) ]

    Gene ID: 512499, updated on 29-Jan-2025

    Summary

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    Official Symbol
    SHARPINprovided by VGNC
    Official Full Name
    SHANK associated RH domain interactorprovided by VGNC
    Primary source
    VGNC:VGNC:34587
    See related
    BGD:BT13280; Ensembl:ENSBTAG00000012235
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SHARPIN in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (732964..737292)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 97 Neighboring gene MAF1 homolog, negative regulator of RNA polymerase III Neighboring gene cytochrome c1 Neighboring gene glycosylphosphatidylinositol anchor attachment 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein linear polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sharpin
    Names
    shank-associated RH domain-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109766.1 → NP_001103236.1  sharpin

      See identical proteins and their annotated locations for NP_001103236.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000014
      UniProtKB/Swiss-Prot
      E1BDF2
      Related
      ENSBTAT00070024403.1
      Conserved Domains (4) summary
      smart00547
      Location:342 → 363
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:342 → 361
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam16764
      Location:13 → 125
      Sharpin_PH; Sharpin PH domain
      cl00155
      Location:219 → 292
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      732964..737292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1BDF2.1 GenPept UniProtKB/Swiss-Prot:E1BDF2

    Gene LinkOut

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    Research Materials