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    BCAR3 BCAR3 adaptor protein, NSP family member [ Bos taurus (domestic cattle) ]

    Gene ID: 506231, updated on 27-Dec-2024

    Summary

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    Official Symbol
    BCAR3provided by VGNC
    Official Full Name
    BCAR3 adaptor protein, NSP family memberprovided by VGNC
    Primary source
    VGNC:VGNC:53850
    See related
    Ensembl:ENSBTAG00000003245
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See BCAR3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (49691045..49912854)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112445876 Neighboring gene microRNA mir-760 Neighboring gene uncharacterized LOC132344998 Neighboring gene uncharacterized LOC112445987 Neighboring gene uncharacterized LOC132344876 Neighboring gene uncharacterized LOC132344877 Neighboring gene formin binding protein 1 like Neighboring gene small nucleolar RNA SNORA16B/SNORA16A family Neighboring gene down-regulator of transcription 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC127863

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    breast cancer anti-estrogen resistance protein 3 homolog
    Names
    BCAR3, NSP family adaptor protein
    breast cancer anti-estrogen resistance 3
    breast cancer antiestrogen resistance 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024483.1 → NP_001019654.1  breast cancer anti-estrogen resistance protein 3 homolog

      See identical proteins and their annotated locations for NP_001019654.1

      Status: PROVISIONAL

      Source sequence(s)
      BT021582
      UniProtKB/Swiss-Prot
      Q2KJF5, Q58DL5
      Related
      ENSBTAP00000055991.1, ENSBTAT00000063777.3
      Conserved Domains (2) summary
      cd10337
      Location:148 → 282
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:545 → 820
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      49691045..49912854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010803299.4 → XP_010801601.1  breast cancer anti-estrogen resistance protein 3 homolog isoform X1

      See identical proteins and their annotated locations for XP_010801601.1

      UniProtKB/Swiss-Prot
      Q2KJF5, Q58DL5
      UniProtKB/TrEMBL
      A0A140T8D6
      Conserved Domains (2) summary
      cd10337
      Location:148 → 282
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:545 → 820
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    2. XM_005204270.5 → XP_005204327.1  breast cancer anti-estrogen resistance protein 3 homolog isoform X1

      See identical proteins and their annotated locations for XP_005204327.1

      UniProtKB/Swiss-Prot
      Q2KJF5, Q58DL5
      UniProtKB/TrEMBL
      A0A140T8D6
      Conserved Domains (2) summary
      cd10337
      Location:148 → 282
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:545 → 820
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    3. XM_024986391.2 → XP_024842159.1  breast cancer anti-estrogen resistance protein 3 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q2KJF5, Q58DL5
      UniProtKB/TrEMBL
      A0A140T8D6
      Conserved Domains (2) summary
      cd10337
      Location:148 → 282
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:545 → 820
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    4. XM_024986399.2 → XP_024842167.1  breast cancer anti-estrogen resistance protein 3 homolog isoform X2

      UniProtKB/Swiss-Prot
      Q2KJF5, Q58DL5
      Conserved Domains (2) summary
      cd10337
      Location:119 → 239
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:502 → 777
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    5. XM_005204269.5 → XP_005204326.1  breast cancer anti-estrogen resistance protein 3 homolog isoform X1

      See identical proteins and their annotated locations for XP_005204326.1

      UniProtKB/Swiss-Prot
      Q2KJF5, Q58DL5
      UniProtKB/TrEMBL
      A0A140T8D6
      Conserved Domains (2) summary
      cd10337
      Location:148 → 282
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:545 → 820
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    6. XM_024986406.2 → XP_024842174.1  breast cancer anti-estrogen resistance protein 3 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q2KJF5, Q58DL5
      UniProtKB/TrEMBL
      A0A140T8D6
      Conserved Domains (2) summary
      cd10337
      Location:148 → 282
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:545 → 820
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    7. XM_005204271.5 → XP_005204328.1  breast cancer anti-estrogen resistance protein 3 homolog isoform X3

      See identical proteins and their annotated locations for XP_005204328.1

      UniProtKB/Swiss-Prot
      Q2KJF5, Q58DL5
      UniProtKB/TrEMBL
      A0A3Q1MN50
      Related
      ENSBTAP00000070920.2, ENSBTAT00000073790.2
      Conserved Domains (2) summary
      cd10337
      Location:57 → 191
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:454 → 729
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    8. XM_015464359.3 → XP_015319845.1  breast cancer anti-estrogen resistance protein 3 homolog isoform X4

      Conserved Domains (1) summary
      cl02485
      Location:220 → 495
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q58DL5.2 GenPept UniProtKB/Swiss-Prot:Q58DL5

    Gene LinkOut

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