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    PBX2 PBX homeobox 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 100139739, updated on 1-Jan-2025

    Summary

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    Official Symbol
    PBX2provided by VGNC
    Official Full Name
    PBX homeobox 2provided by VGNC
    Primary source
    VGNC:VGNC:32608
    See related
    BGD:BT13902; Ensembl:ENSBTAG00000014421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PBX2 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (27197849..27205663)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene butyrophilin-like protein 1 Neighboring gene notch receptor 4 Neighboring gene advanced glycosylation end-product specific receptor Neighboring gene ring finger protein 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. YAC/BAC contig spanning the MHC class III region of cattle. Gelhaus A, et al. Cytogenet Genome Res, 2006. PMID 16974083
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in embryonic organ development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in eye development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pre-B-cell leukemia transcription factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256883.1 → NP_001243812.1  pre-B-cell leukemia transcription factor 2

      See identical proteins and their annotated locations for NP_001243812.1

      Status: VALIDATED

      Source sequence(s)
      DY089880, DY097143, EE389114, NKLS02000023
      UniProtKB/TrEMBL
      F1MQ55
      Conserved Domains (2) summary
      cd00086
      Location:245 → 305
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03792
      Location:50 → 243
      PBC; PBC domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27197849..27205663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015459864.3 → XP_015315350.1  pre-B-cell leukemia transcription factor 2 isoform X1

      UniProtKB/TrEMBL
      A0AAA9THD8, F1MQ55
      Related
      ENSBTAP00000053543.4, ENSBTAT00000061322.4
      Conserved Domains (2) summary
      cd00086
      Location:304 → 364
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03792
      Location:117 → 302
      PBC; PBC domain

    2. XM_015459865.3 → XP_015315351.1  pre-B-cell leukemia transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      A0AAA9THD8
      Related
      ENSBTAP00000097662.1, ENSBTAT00000112831.1
      Conserved Domains (2) summary
      cd00086
      Location:303 → 363
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03792
      Location:108 → 301
      PBC; PBC domain

    3. XM_024983366.2 → XP_024839134.1  pre-B-cell leukemia transcription factor 2 isoform X3

      Conserved Domains (2) summary
      cd00086
      Location:185 → 245
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03792
      Location:1 → 183
      PBC; PBC domain

    4. XM_059880189.1 → XP_059736172.1  pre-B-cell leukemia transcription factor 2 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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