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    NCOA1 nuclear receptor coactivator 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 525346, updated on 29-Jan-2025

    Summary

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    Official Symbol
    NCOA1provided by VGNC
    Official Full Name
    nuclear receptor coactivator 1provided by VGNC
    Primary source
    VGNC:VGNC:97291
    See related
    Ensembl:ENSBTAG00000015007
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NCOA1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (74447679..74666712, complement)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2 Neighboring gene adenylate cyclase 3 Neighboring gene centromere protein O Neighboring gene peptidyl-tRNA hydrolase domain containing 1 Neighboring gene uncharacterized LOC112448948 Neighboring gene intersectin 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nuclear receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear receptor coactivator 1
    NP_001193144.1
    XP_024854524.1
    XP_024854525.1
    XP_024854526.1
    XP_024854527.1
    XP_024854528.1
    XP_024854529.1
    XP_024854530.1
    XP_059747268.1
    XP_059747270.1
    XP_059747271.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206215.1 → NP_001193144.1  nuclear receptor coactivator 1

      See identical proteins and their annotated locations for NP_001193144.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000011
      UniProtKB/TrEMBL
      G3N0C2
      Related
      ENSBTAP00070037952.1, ENSBTAT00070063230.1
      Conserved Domains (9) summary
      smart00353
      Location:32 → 86
      HLH; helix loop helix domain
      cd00130
      Location:120 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1212 → 1268
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:924 → 970
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:632 → 708
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:974 → 1359
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:260 → 370
      PAS_11; PAS domain
      pfam16279
      Location:741 → 818
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:468 → 590
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      74447679..74666712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024998757.2 → XP_024854525.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/TrEMBL
      G3N0C2
      Conserved Domains (9) summary
      smart00353
      Location:32 → 86
      HLH; helix loop helix domain
      cd00130
      Location:120 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1212 → 1268
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:924 → 970
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:632 → 708
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:974 → 1359
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:260 → 370
      PAS_11; PAS domain
      pfam16279
      Location:741 → 818
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:468 → 590
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    2. XM_024998760.2 → XP_024854528.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/TrEMBL
      G3N0C2
      Conserved Domains (9) summary
      smart00353
      Location:32 → 86
      HLH; helix loop helix domain
      cd00130
      Location:120 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1212 → 1268
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:924 → 970
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:632 → 708
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:974 → 1359
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:260 → 370
      PAS_11; PAS domain
      pfam16279
      Location:741 → 818
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:468 → 590
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    3. XM_024998762.2 → XP_024854530.1  nuclear receptor coactivator 1 isoform X2

      Conserved Domains (9) summary
      smart00353
      Location:32 → 86
      HLH; helix loop helix domain
      cd00130
      Location:120 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1212 → 1268
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:924 → 970
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:632 → 708
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:974 → 1359
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:260 → 370
      PAS_11; PAS domain
      pfam16279
      Location:741 → 818
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:468 → 590
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    4. XM_024998756.2 → XP_024854524.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/TrEMBL
      G3N0C2
      Conserved Domains (9) summary
      smart00353
      Location:32 → 86
      HLH; helix loop helix domain
      cd00130
      Location:120 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1212 → 1268
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:924 → 970
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:632 → 708
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:974 → 1359
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:260 → 370
      PAS_11; PAS domain
      pfam16279
      Location:741 → 818
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:468 → 590
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    5. XM_024998759.2 → XP_024854527.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/TrEMBL
      G3N0C2
      Conserved Domains (9) summary
      smart00353
      Location:32 → 86
      HLH; helix loop helix domain
      cd00130
      Location:120 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1212 → 1268
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:924 → 970
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:632 → 708
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:974 → 1359
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:260 → 370
      PAS_11; PAS domain
      pfam16279
      Location:741 → 818
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:468 → 590
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    6. XM_024998761.2 → XP_024854529.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/TrEMBL
      G3N0C2
      Conserved Domains (9) summary
      smart00353
      Location:32 → 86
      HLH; helix loop helix domain
      cd00130
      Location:120 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1212 → 1268
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:924 → 970
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:632 → 708
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:974 → 1359
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:260 → 370
      PAS_11; PAS domain
      pfam16279
      Location:741 → 818
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:468 → 590
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    7. XM_024998758.2 → XP_024854526.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/TrEMBL
      G3N0C2
      Conserved Domains (9) summary
      smart00353
      Location:32 → 86
      HLH; helix loop helix domain
      cd00130
      Location:120 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam07469
      Location:1212 → 1268
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:924 → 970
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:632 → 708
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:974 → 1359
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:260 → 370
      PAS_11; PAS domain
      pfam16279
      Location:741 → 818
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:468 → 590
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    8. XM_059891285.1 → XP_059747268.1  nuclear receptor coactivator 1 isoform X1

      UniProtKB/TrEMBL
      G3N0C2

    9. XM_059891287.1 → XP_059747270.1  nuclear receptor coactivator 1 isoform X3

      UniProtKB/TrEMBL
      E1BK04

    10. XM_059891288.1 → XP_059747271.1  nuclear receptor coactivator 1 isoform X3

      UniProtKB/TrEMBL
      E1BK04
      Related
      ENSBTAP00070037938.1, ENSBTAT00070063210.1
    Nucleotide Protein Strain
    Heading Accession and Version

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