PGRMC1 progesterone receptor membrane component 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PGRMC1provided by VGNC
Official Full Name: progesterone receptor membrane component 1provided by VGNC
Primary source: VGNC:VGNC:32801
See related: BGD:BT27888; Ensembl:ENSBTAG00000019552
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: mPR
Orthologs: human mouse all
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Genomic context

Location:: chromosome: X

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	X	NC_037357.1 (3623768..3632155)

Chromosome X - NC_037357.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PGRMC1 participates in late events of both mammalian mitosis and oocyte meiosis, consistent with PGRMC1's localization at the mid-zone and mid-body of the mitotic and meiotic spindle.
Title: PGRMC1 participates in late events of bovine granulosa cells mitosis and oocyte meiosis.
PGRMC1 protein expression and cellular distribution in cumulus cells
Title: Expression and cellular distribution of estrogen and progesterone receptors and the real-time proliferation of porcine cumulus cells.
data indicate variable expression of progesterone receptor membrane component 1 and 2 and serpine mRNA binding protein 1 mRNA and protein in bovine corpus luteum and suggest that progesterone may regulate corpus luteum function via its membrane receptors
Title: Expression and localization of progesterone receptor membrane component 1 and 2 and serpine mRNA binding protein 1 in the bovine corpus luteum during the estrous cycle and the first trimester of pregnancy.
endometrial mRNA level elevated during pregnancy is unchanged during estrous cycle
Title: Expression of progesterone receptor membrane component (PGRMC) 1 and 2, serpine mRNA binding protein 1 (SERBP1) and nuclear progesterone receptor (PGR) in the bovine endometrium during the estrous cycle and the first trimester of pregnancy.
Alterations in PGRMC1 and/or AURKB localization account in part for the increased aneuploidy and low development competence of oocytes from ovaries with reduced antral follicle counts.
Title: Oocytes isolated from dairy cows with reduced ovarian reserve have a high frequency of aneuploidy and alterations in the localization of progesterone receptor membrane component 1 and aurora kinase B.
Data suggest that expression of PGRMC1 in bovine oviduct is primarily in luminal epithelium and is primarily cytoplasmic. Expression of PR (progesterone receptor), PGRMC1, and PGRMC2 are not affected by pregnancy or presence of corpus luteum.
Title: Expression of nuclear progesterone receptor and progesterone receptor membrane components 1 and 2 in the oviduct of cyclic and pregnant cows during the post-ovulation period.
analysis of expression of progesterone receptor membrane component 1, serpine mRNA binding protein 1 and nuclear progesterone receptor isoforms A and B in the bovine myometrium during the estrous cycle and early pregnancy
Title: Expression of progesterone receptor membrane component 1, serpine mRNA binding protein 1 and nuclear progesterone receptor isoforms A and B in the bovine myometrium during the estrous cycle and early pregnancy.
With the exception of the corpora lutea, PGRMC1 localization showed similar pattern during different stages of the estrous cycle.
Title: Expression of progesterone receptor membrane component-1 in bovine reproductive system during estrous cycle.
PGRMC1 is expressed in bovine oocytes and its localization changes at specific stages of oocyte maturation, which may be specifically related to the mechanism by which chromosomes segregate.
Title: Progesterone receptor membrane component 1 expression and putative function in bovine oocyte maturation, fertilization, and early embryonic development.
PGRMC1 mRNA is expressed in bovine CL and this expression varies throughout the luteal phase. It is assumed that PGRMC1 may be involved in a non-genomic effect of P(4) on luteal cells.
Title: Progesterone receptor membrane component 1 (PGRMC1) gene expression in corpus luteum during the estrous cycle in cows.

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General gene information

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Gene Ontology Provided by RefSeq

Component	Evidence Code	Pubs
located_in endomembrane system	IEA Inferred from Electronic Annotation more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: membrane-associated progesterone receptor component 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.