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    TRIP12 thyroid hormone receptor interactor 12 [ Bos taurus (domestic cattle) ]

    Gene ID: 514387, updated on 1-Jan-2025

    Summary

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    Official Symbol
    TRIP12provided by VGNC
    Official Full Name
    thyroid hormone receptor interactor 12provided by VGNC
    Primary source
    VGNC:VGNC:36358
    See related
    BGD:BT11970; Ensembl:ENSBTAG00000021653
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    TRIP-12
    Orthologs
    human mouse all
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    Genomic context

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    See TRIP12 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (117807931..117963006, complement)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene delta/notch like EGF repeat containing Neighboring gene microRNA mir-2284m Neighboring gene uncharacterized LOC132342862 Neighboring gene uncharacterized LOC132343306 Neighboring gene U6 spliceosomal RNA Neighboring gene F-box protein 36 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIP12
    Names
    HECT-type E3 ubiquitin transferase TRIP12
    TR-interacting protein 12
    thyroid receptor-interacting protein 12
    NP_001178132.1
    XP_015314969.1
    XP_024856982.1
    XP_024856990.1
    XP_024857003.1
    XP_024857006.1
    XP_024857023.1
    XP_024857031.1
    XP_024857035.1
    XP_024857037.1
    XP_024857041.1
    XP_024857051.1
    XP_024857058.1
    XP_024857070.1
    XP_024857078.1
    XP_024857096.1
    XP_024857097.1
    XP_059749222.1
    XP_059749225.1
    XP_059749229.1
    XP_059749235.1
    XP_059749238.1
    XP_059749241.1
    XP_059749264.1
    XP_059749271.1
    XP_059749279.1
    XP_059749286.1
    XP_059749296.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191203.1 → NP_001178132.1  E3 ubiquitin-protein ligase TRIP12

      See identical proteins and their annotated locations for NP_001178132.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000002
      UniProtKB/Swiss-Prot
      E1B7Q7, Q0P5M6
      UniProtKB/TrEMBL
      A0A3Q1M409
      Related
      ENSBTAP00000064519.1, ENSBTAT00000071197.2
      Conserved Domains (3) summary
      smart00119
      Location:1608 → 1986
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1590 → 1990
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:760 → 798
      WWE; WWE domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      117807931..117963006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059893252.1 → XP_059749235.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SCB6, A0AAA9TW48

    2. XM_059893255.1 → XP_059749238.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SCB6, A0AAA9TW48

    3. XM_059893296.1 → XP_059749279.1  E3 ubiquitin-protein ligase TRIP12 isoform X12

      UniProtKB/TrEMBL
      A0A3Q1M409

    4. XM_059893242.1 → XP_059749225.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SCB6, A0AAA9TW48

    5. XM_025001328.2 → XP_024857096.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      A0A3Q1M409
      Conserved Domains (4) summary
      cd00078
      Location:1594 → 1994
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:737 → 802
      WWE; WWE domain
      cl25709
      Location:418 → 643
      Arm_3; Atypical Arm repeat
      cl25758
      Location:44 → 176
      DUF4775; Domain of unknown function (DUF4775)

    6. XM_025001329.2 → XP_024857097.1  E3 ubiquitin-protein ligase TRIP12 isoform X17

      UniProtKB/TrEMBL
      A0A3Q1M409
      Conserved Domains (4) summary
      cd00078
      Location:1591 → 1991
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:766 → 804
      WWE; WWE domain
      cl25709
      Location:447 → 672
      Arm_3; Atypical Arm repeat
      cl25758
      Location:44 → 176
      DUF4775; Domain of unknown function (DUF4775)

    7. XM_025001310.2 → XP_024857078.1  E3 ubiquitin-protein ligase TRIP12 isoform X14

      UniProtKB/TrEMBL
      A0A3Q1M409
      Conserved Domains (4) summary
      cd00078
      Location:1618 → 2018
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:766 → 831
      WWE; WWE domain
      cl25709
      Location:447 → 672
      Arm_3; Atypical Arm repeat
      cl25758
      Location:44 → 176
      DUF4775; Domain of unknown function (DUF4775)

    8. XM_025001290.2 → XP_024857058.1  E3 ubiquitin-protein ligase TRIP12 isoform X12

      UniProtKB/TrEMBL
      A0A3Q1M409
      Conserved Domains (4) summary
      cd00078
      Location:1623 → 2023
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:766 → 831
      WWE; WWE domain
      cl25709
      Location:447 → 672
      Arm_3; Atypical Arm repeat
      cl25758
      Location:44 → 176
      DUF4775; Domain of unknown function (DUF4775)

    9. XM_025001302.2 → XP_024857070.1  E3 ubiquitin-protein ligase TRIP12 isoform X13

      UniProtKB/TrEMBL
      A0A3Q1M409
      Conserved Domains (4) summary
      cd00078
      Location:1619 → 2019
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:766 → 832
      WWE; WWE domain
      cl25709
      Location:447 → 672
      Arm_3; Atypical Arm repeat
      cl25758
      Location:44 → 176
      DUF4775; Domain of unknown function (DUF4775)

    10. XM_059893288.1 → XP_059749271.1  E3 ubiquitin-protein ligase TRIP12 isoform X11

      UniProtKB/TrEMBL
      A0A3Q1M409, A0AAA9SS51
      Related
      ENSBTAP00000086799.1, ENSBTAT00000116020.1

    11. XM_025001283.2 → XP_024857051.1  E3 ubiquitin-protein ligase TRIP12 isoform X10

      UniProtKB/TrEMBL
      A0AAA9SCB6
      Conserved Domains (4) summary
      cd00078
      Location:1631 → 2031
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:779 → 844
      WWE; WWE domain
      cl25709
      Location:460 → 685
      Arm_3; Atypical Arm repeat
      cl25751
      Location:40 → 205
      DUF4045; Domain of unknown function (DUF4045)

    12. XM_059893281.1 → XP_059749264.1  E3 ubiquitin-protein ligase TRIP12 isoform X8

      UniProtKB/TrEMBL
      A0AAA9SCB6, A0AAA9TWW7
      Related
      ENSBTAP00000101086.1, ENSBTAT00000107993.1

    13. XM_025001267.2 → XP_024857035.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

      UniProtKB/TrEMBL
      A0AAA9SCB6
      Conserved Domains (4) summary
      cd00078
      Location:1637 → 2037
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:779 → 845
      WWE; WWE domain
      cl25709
      Location:460 → 685
      Arm_3; Atypical Arm repeat
      cl25751
      Location:40 → 205
      DUF4045; Domain of unknown function (DUF4045)

    14. XM_025001273.2 → XP_024857041.1  E3 ubiquitin-protein ligase TRIP12 isoform X9

      UniProtKB/TrEMBL
      A0A3Q1M409
      Conserved Domains (4) summary
      cd00078
      Location:1633 → 2033
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 846
      WWE; WWE domain
      pfam05110
      Location:5 → 218
      AF-4; AF-4 proto-oncoprotein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    15. XM_025001263.2 → XP_024857031.1  E3 ubiquitin-protein ligase TRIP12 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1M409
      Conserved Domains (4) summary
      cd00078
      Location:1638 → 2038
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 846
      WWE; WWE domain
      pfam05110
      Location:5 → 218
      AF-4; AF-4 proto-oncoprotein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    16. XM_025001238.2 → XP_024857006.1  E3 ubiquitin-protein ligase TRIP12 isoform X4

      UniProtKB/TrEMBL
      A0AAA9SCB6
      Conserved Domains (4) summary
      cd00078
      Location:1660 → 2060
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 873
      WWE; WWE domain
      pfam05110
      Location:5 → 218
      AF-4; AF-4 proto-oncoprotein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    17. XM_025001222.2 → XP_024856990.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

      UniProtKB/TrEMBL
      A0AAA9SCB6, A0AAF6ZDJ0
      Related
      ENSBTAP00000037967.4, ENSBTAT00000038151.5
      Conserved Domains (4) summary
      cd00078
      Location:1665 → 2065
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 873
      WWE; WWE domain
      pfam05110
      Location:5 → 218
      AF-4; AF-4 proto-oncoprotein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    18. XM_025001255.2 → XP_024857023.1  E3 ubiquitin-protein ligase TRIP12 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1M409
      Conserved Domains (4) summary
      cd00078
      Location:1639 → 2039
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 847
      WWE; WWE domain
      pfam05110
      Location:5 → 218
      AF-4; AF-4 proto-oncoprotein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    19. XM_025001235.2 → XP_024857003.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

      UniProtKB/TrEMBL
      A0AAA9SCB6
      Conserved Domains (4) summary
      cd00078
      Location:1661 → 2061
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 874
      WWE; WWE domain
      pfam05110
      Location:5 → 218
      AF-4; AF-4 proto-oncoprotein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    20. XM_025001214.2 → XP_024856982.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SCB6, A0AAA9TW48
      Related
      ENSBTAP00000101407.1, ENSBTAT00000099853.1
      Conserved Domains (4) summary
      cd00078
      Location:1666 → 2066
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 874
      WWE; WWE domain
      pfam05110
      Location:5 → 218
      AF-4; AF-4 proto-oncoprotein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    21. XM_059893303.1 → XP_059749286.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

      UniProtKB/TrEMBL
      A0A3Q1M409

    22. XM_059893246.1 → XP_059749229.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SCB6, A0AAA9TW48

    23. XM_059893239.1 → XP_059749222.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SCB6, A0AAA9TW48

    24. XM_015459483.3 → XP_015314969.1  E3 ubiquitin-protein ligase TRIP12 isoform X12

      UniProtKB/TrEMBL
      A0A3Q1M409
      Conserved Domains (4) summary
      cd00078
      Location:1623 → 2023
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:766 → 831
      WWE; WWE domain
      cl25709
      Location:447 → 672
      Arm_3; Atypical Arm repeat
      cl25758
      Location:44 → 176
      DUF4775; Domain of unknown function (DUF4775)

    25. XM_025001269.2 → XP_024857037.1  E3 ubiquitin-protein ligase TRIP12 isoform X8

      UniProtKB/TrEMBL
      A0AAA9SCB6, A0AAA9TWW7
      Conserved Domains (4) summary
      cd00078
      Location:1636 → 2036
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:779 → 844
      WWE; WWE domain
      cl25709
      Location:460 → 685
      Arm_3; Atypical Arm repeat
      cl25751
      Location:40 → 205
      DUF4045; Domain of unknown function (DUF4045)

    26. XM_059893258.1 → XP_059749241.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SCB6, A0AAA9TW48

    27. XM_059893313.1 → XP_059749296.1  E3 ubiquitin-protein ligase TRIP12 isoform X18

      UniProtKB/TrEMBL
      A0A3Q1M409
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1B7Q7.2 GenPept UniProtKB/Swiss-Prot:E1B7Q7

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