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    TERF1 telomeric repeat binding factor 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 519474, updated on 30-Jan-2025

    Summary

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    Official Symbol
    TERF1provided by VGNC
    Official Full Name
    telomeric repeat binding factor 1provided by VGNC
    Primary source
    VGNC:VGNC:35749
    See related
    BGD:BT27347; EnsemblRapid:ENSBTAG00070007934
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TERF1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (36382268..36425376)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily B member 2 Neighboring gene microRNA mir-1603 Neighboring gene U6 spliceosomal RNA Neighboring gene somatomedin B and thrombospondin type 1 domain containing Neighboring gene chromosome 14 C8orf89 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding, bending IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables G-rich strand telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ankyrin repeat binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables double-stranded telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables telomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of telomeric D-loop disassembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of nuclear telomere cap complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    telomeric repeat-binding factor 1
    Names
    telomeric repeat binding factor (NIMA-interacting) 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076865.2 → NP_001070333.2  telomeric repeat-binding factor 1

      Status: VALIDATED

      Source sequence(s)
      DAAA02038833, DV828419, EV614740
      UniProtKB/TrEMBL
      G3X7V3, Q3MHY0
      Related
      ENSBTAP00070010442.1, ENSBTAT00070017898.1
      Conserved Domains (2) summary
      cd11660
      Location:378 → 426
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
      cd00280
      Location:64 → 260
      TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      36382268..36425376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005215517.5 → XP_005215574.2  telomeric repeat-binding factor 1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9S2R5, G3X7V3, Q3MHY0
      Related
      ENSBTAP00070010472.1, ENSBTAT00070017940.1
      Conserved Domains (2) summary
      cd11660
      Location:358 → 406
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
      cd00280
      Location:64 → 260
      TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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