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    FHL1 four and a half LIM domains 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 509056, updated on 27-Dec-2024

    Summary

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    Official Symbol
    FHL1provided by VGNC
    Official Full Name
    four and a half LIM domains 1provided by VGNC
    Primary source
    VGNC:VGNC:28999
    See related
    BGD:BT16728; Ensembl:ENSBTAG00000018513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See FHL1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) Unplaced Scaffold NW_020192292.1 (8690290..8755071, complement)

    NW_020192292.1Genomic Context describing neighboring genes Neighboring gene adhesion G-protein coupled receptor G4-like Neighboring gene MAP7 domain containing 3 Neighboring gene solute carrier family 9 member A6 Neighboring gene membrane magnesium transporter 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_020192292 Unplaced Scaffold Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC127148

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    four and a half LIM domains protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034341.1 → NP_001029513.1  four and a half LIM domains protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001029513.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) omits an inframe coding exon resulting in a shorter isoform (3).
      Source sequence(s)
      BC102083
      UniProtKB/TrEMBL
      Q3T173
      Related
      ENSBTAP00000024644.4, ENSBTAT00000024644.6
      Conserved Domains (3) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. NM_001113258.1 → NP_001106729.1  four and a half LIM domains protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001106729.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses a different first exon resulting in a longer predicted protein isoform (1).
      Source sequence(s)
      DV893453, DV931938, EE390515
      UniProtKB/TrEMBL
      F1MR86
      Related
      ENSBTAP00000081263.1, ENSBTAT00000095735.1
      Conserved Domains (5) summary
      cd09344
      Location:56 → 109
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09348
      Location:233 → 296
      LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09424
      Location:117 → 174
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:178 → 230
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:21 → 49
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. NM_001113259.1 → NP_001106730.1  four and a half LIM domains protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001106730.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different first exon resulting in a shorter predicted protein isoform (2) compared to variant 1.
      Source sequence(s)
      DT836907, DV820968, DV890085, DV893453, EE346729
      UniProtKB/TrEMBL
      G3MZ95
      Related
      ENSBTAP00000054891.2, ENSBTAT00000063425.3
      Conserved Domains (5) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09348
      Location:217 → 280
      LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162 → 214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NW_020192292.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      8690290..8755071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024989315.2 → XP_024845083.1  four and a half LIM domains protein 1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TLW1, F1MR86
      Related
      ENSBTAP00000099441.1, ENSBTAT00000092278.1
      Conserved Domains (4) summary
      cd09344
      Location:56 → 109
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:117 → 174
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:178 → 230
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:21 → 49
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_024989319.2 → XP_024845087.1  four and a half LIM domains protein 1 isoform X2

      UniProtKB/TrEMBL
      F1MR86
      Conserved Domains (4) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162 → 214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_024989317.2 → XP_024845085.1  four and a half LIM domains protein 1 isoform X2

      UniProtKB/TrEMBL
      F1MR86
      Conserved Domains (4) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162 → 214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version

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