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    TPK1 thiamin pyrophosphokinase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 788066, updated on 27-Dec-2024

    Summary

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    Official Symbol
    TPK1provided by VGNC
    Official Full Name
    thiamin pyrophosphokinase 1provided by VGNC
    Primary source
    VGNC:VGNC:36251
    See related
    BGD:BT29749; Ensembl:ENSBTAG00000017676
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TPK1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (107718447..108101146, complement)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112446451 Neighboring gene Rho guanine nucleotide exchange factor 5 Neighboring gene NOBOX oogenesis homeobox Neighboring gene contactin associated protein 2 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene cullin 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables thiamine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables thiamine diphosphokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in thiamine diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in thiamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thiamine pyrophosphokinase 1
    NP_001073839.1
    XP_005205956.1
    XP_024846702.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080370.1 → NP_001073839.1  thiamine pyrophosphokinase 1

      See identical proteins and their annotated locations for NP_001073839.1

      Status: PROVISIONAL

      Source sequence(s)
      BC119895
      UniProtKB/Swiss-Prot
      Q0P5L2, Q5E9T4
      UniProtKB/TrEMBL
      A0AAF6Z455
      Related
      ENSBTAP00000023510.4, ENSBTAT00000023510.5
      Conserved Domains (1) summary
      cl27179
      Location:21 → 241
      TPK_B1_binding; Thiamin pyrophosphokinase, vitamin B1 binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      107718447..108101146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024990934.2 → XP_024846702.1  thiamine pyrophosphokinase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q0P5L2, Q5E9T4
      UniProtKB/TrEMBL
      A0AAF6Z455
      Conserved Domains (1) summary
      cl27179
      Location:21 → 241
      TPK_B1_binding; Thiamin pyrophosphokinase, vitamin B1 binding domain

    2. XM_005205899.3 → XP_005205956.1  thiamine pyrophosphokinase 1 isoform X1

      See identical proteins and their annotated locations for XP_005205956.1

      UniProtKB/Swiss-Prot
      Q0P5L2, Q5E9T4
      UniProtKB/TrEMBL
      A0AAF6Z455
      Related
      ENSBTAP00000041553.1, ENSBTAT00000044036.2
      Conserved Domains (1) summary
      cl27179
      Location:21 → 241
      TPK_B1_binding; Thiamin pyrophosphokinase, vitamin B1 binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5E9T4.1 GenPept UniProtKB/Swiss-Prot:Q5E9T4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.