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    PTGR1 prostaglandin reductase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 513177, updated on 27-Dec-2024

    Summary

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    Official Symbol
    PTGR1provided by VGNC
    Official Full Name
    prostaglandin reductase 1provided by VGNC
    Primary source
    VGNC:VGNC:33510
    See related
    BGD:BT20556; Ensembl:ENSBTAG00000011027
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    DIG-1; LTB4DH
    Orthologs
    human mouse all
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    Genomic context

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    See PTGR1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (100963668..100994111, complement)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene Ecm29 proteasome adaptor and scaffold Neighboring gene zinc finger protein 483 Neighboring gene pleckstrin homology domain-containing family A member 1-like Neighboring gene DnaJ heat shock protein family (Hsp40) member C25 Neighboring gene G protein subunit gamma 10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC127457

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables 2-alkenal reductase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in prostaglandin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prostaglandin reductase 1
    Names
    15-oxoprostaglandin 13-reductase
    D3T-inducible gene 1 protein
    NAD(P)H-dependent alkenal/one oxidoreductase
    NADP-dependent leukotriene B4 12-hydroxydehydrogenase
    PRG-1
    dithiolethione-inducible gene 1 protein
    leukotriene B4 12-hydroxydehydrogenase
    NP_001030358.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035281.2 → NP_001030358.1  prostaglandin reductase 1

      Status: PROVISIONAL

      Source sequence(s)
      BC102822
      UniProtKB/Swiss-Prot
      Q3SZJ4
      UniProtKB/TrEMBL
      A0AAA9SHZ4
      Related
      ENSBTAP00000014649.3, ENSBTAT00000014649.4
      Conserved Domains (2) summary
      TIGR02825
      Location:4 → 328
      B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
      cd08294
      Location:2 → 329
      leukotriene_B4_DH_like; 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      100963668..100994111 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3SZJ4.1 GenPept UniProtKB/Swiss-Prot:Q3SZJ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.