GJA1 gap junction protein alpha 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: GJA1provided by VGNC
Official Full Name: gap junction protein alpha 1provided by VGNC
Primary source: VGNC:VGNC:29370
See related: BGD:BT17449; Ensembl:ENSBTAG00000001835
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: CXNK1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	9	NC_037336.1 (29748655..29761667, complement)

Chromosome 9 - NC_037336.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BPA and BPS Affect Connexin 37 in Bovine Cumulus Cells.
Title: BPA and BPS Affect Connexin 37 in Bovine Cumulus Cells.
Preservation of connexin 43 and transzonal projections in isolated bovine pre-antral follicles before and following vitrification.
Title: Preservation of connexin 43 and transzonal projections in isolated bovine pre-antral follicles before and following vitrification.
cumulus-oocyte complexes and granulosa cells exposed to ATRA during maturation had significantly higher CX43 expression and increased gap junctional coupling, respectively.
Title: All-trans retinoic acid exposure increases connexin 43 expression in cumulus cells and improves embryo development in bovine oocytes.
This study found that down-regulation of Cx43 expression in the junction zone might play an important role in pathogenesis of adenomyosis, and that estradiol modulates gap junctions during adenomyosis.
Title: Estradiol Reduces Connexin43 Gap Junctions in the Uterus during Adenomyosis in Cows.
Cx43 mRNA and protein expression increased after endothelial cell exposure to ketone bodies; this was accompanied by upregulation of gap junctional intercellular coupling and cell migration.
Title: Ketone bodies upregulate endothelial connexin 43 (Cx43) gap junctions.
RhoA appears to be an important molecular switch that controls Cx43 hemichannel openings and hemichannel-mediated ATP-dependent paracrine intercellular communication under (patho)physiological conditions of stress
Title: RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system.
Papillary urothelial carcinomas showed moderate cytoplasmic and membrane labelling, while invasive carcinoma showed loss of connexin 43 expression.
Title: Expression of gap junction protein connexin 43 in bovine urinary bladder tumours.
Results describe the effect of suppression of connexin 43 and E-cadherin on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.
Title: Suppression of connexin 43 and E-cadherin transcripts in in vitro derived bovine embryos following culture in vitro or in vivo in the homologous bovine oviduct.
Human TGF-beta1 induces an accumulation of connexin43 in a lysosomal compartment in bovine endothelial cells
Title: TGF-beta1 induces an accumulation of connexin43 in a lysosomal compartment in endothelial cells.
intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26, Cx32, and Cx43
Title: Expression of gap junctional connexins 26, 32 and 43 in bovine placentomes during pregnancy.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

PMC151788P1 (e-PCR)
- UniSTS:271174

GJA1 (e-PCR)
- UniSTS:278477

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables gap junction channel activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell communication by electrical coupling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in heart development	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of connexin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: gap junction alpha-1 protein

Names: connexin K1; connexin-43; cx43; gap junction protein, alpha 1, 43 kD (connexin 43); gap junction protein, alpha 1, 43kDa; vascular smooth muscle connexin-43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.