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    FES FES proto-oncogene, tyrosine kinase [ Bos taurus (domestic cattle) ]

    Gene ID: 507304, updated on 27-Dec-2024

    Summary

    Official Symbol
    FESprovided by VGNC
    Official Full Name
    FES proto-oncogene, tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:28954
    See related
    BGD:BT29933; Ensembl:ENSBTAG00000002941
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    NEW
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    Genomic context

    See FES in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (21768206..21779656, complement)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene mannosidase alpha class 2A member 2 Neighboring gene HD domain containing 3 Neighboring gene furin, paired basic amino acid cleaving enzyme Neighboring gene BLM RecQ like helicase Neighboring gene uncharacterized LOC107131599

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

    Expression

    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in regulation of mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine-protein kinase Fes/Fps
    Names
    V-FES feline sarcoma viral/V-FPS fujinami avian sarcoma viral oncogene homolog
    c-fes proto-oncogene protein
    feline sarcoma oncogene
    feline sarcoma viral (v-fes) oncogene
    v-fps oncogene homolog
    NP_001027471.1
    XP_024837443.1
    XP_024837444.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032300.1NP_001027471.1  tyrosine-protein kinase Fes/Fps

      See identical proteins and their annotated locations for NP_001027471.1

      Status: PROVISIONAL

      Source sequence(s)
      BT020947
      UniProtKB/TrEMBL
      A0AAA9SZE9, Q5E9H3
      Related
      ENSBTAP00000003828.4, ENSBTAT00000003828.6
      Conserved Domains (3) summary
      cd07685
      Location:7239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl21453
      Location:564815
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      21768206..21779656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024981675.2XP_024837443.1  tyrosine-protein kinase Fes/Fps isoform X1

      UniProtKB/TrEMBL
      A0AAA9SZE9, Q5E9H3
      Conserved Domains (3) summary
      cd07685
      Location:7239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl21453
      Location:564815
      PKc_like; Protein Kinases, catalytic domain
    2. XM_024981676.2XP_024837444.1  tyrosine-protein kinase Fes/Fps isoform X1

      UniProtKB/TrEMBL
      A0AAA9SZE9, Q5E9H3
      Conserved Domains (3) summary
      cd07685
      Location:7239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl21453
      Location:564815
      PKc_like; Protein Kinases, catalytic domain