DR1 down-regulator of transcription 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: DR1provided by VGNC
Official Full Name: down-regulator of transcription 1provided by VGNC
Primary source: VGNC:VGNC:28200
See related: BGD:BT30066; Ensembl:ENSBTAG00000008737
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (50084783..50106905, complement)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RNA polymerase II general transcription initiation factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables TBP-class protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of negative cofactor 2 complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein Dr1

Names: down-regulator of transcription 1, TBP-binding (negative cofactor 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001046519.1 → NP_001039984.1 protein Dr1

See identical proteins and their annotated locations for NP_001039984.1

Status: PROVISIONAL

Source sequence(s)

BC105564

UniProtKB/TrEMBL

Q2KJ19

Related

ENSBTAP00000011514.2, ENSBTAT00000011514.3

Conserved Domains (1) summary

cl23735
Location:7 → 130

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...