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    KLRK1 killer cell lectin like receptor K1 [ Bos taurus (domestic cattle) ]

    Gene ID: 404058, updated on 29-Jan-2025

    Summary

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    Gene symbol
    KLRK1
    Gene description
    killer cell lectin like receptor K1
    See related
    BGD:BT24893; Ensembl:ENSBTAG00000004917
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    KLRC; NKG2-D
    Orthologs
    human mouse all
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    Genomic context

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    See KLRK1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (99603137..99613786)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene NKG2C protein Neighboring gene uncharacterized LOC100847813 Neighboring gene killer cell lectin-like receptor subfamily D, member 1 Neighboring gene natural killer cells antigen CD94

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Cattle MIC is a ligand for the activating NK cell receptor NKG2D. Guzman E, et al. Vet Immunol Immunopathol, 2010 Aug 15. PMID 20399506
    2. Homologues of natural killer cell receptors NKG2-D and NKR-P1 expressed in cattle. Govaerts MM, et al. Vet Immunol Immunopathol, 2001 Aug 10. PMID 11457486
    3. Cloning, sequencing, and cell surface expression pattern of bovine immunoreceptor NKG2D and adaptor molecules DAP10 and DAP12. Fikri Y, et al. Immunogenetics, 2007 Aug. PMID 17530242
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NKG2D is a functionally important activating receptor in cattle
      Title: Cattle MIC is a ligand for the activating NK cell receptor NKG2D.
    2. cloning, sequencing, and cell surface expression pattern
      Title: Cloning, sequencing, and cell surface expression pattern of bovine immunoreceptor NKG2D and adaptor molecules DAP10 and DAP12.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of natural killer cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NKG2-D type II integral membrane protein
    Names
    killer cell lectin-like receptor subfamily C
    killer cell lectin-like receptor subfamily K, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075139.1 → NP_001068607.1  NKG2-D type II integral membrane protein

      See identical proteins and their annotated locations for NP_001068607.1

      Status: PROVISIONAL

      Source sequence(s)
      AM075206
      UniProtKB/TrEMBL
      A0A3Q1NI22, Q1XF12
      Related
      ENSBTAP00070038812.1, ENSBTAT00070064566.1
      Conserved Domains (1) summary
      cd03593
      Location:85 → 199
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      99603137..99613786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059886139.1 → XP_059742122.1  NKG2-D type II integral membrane protein isoform X1

      UniProtKB/TrEMBL
      A0A3Q1NI22, F1MI53
      Related
      ENSBTAP00070038781.1, ENSBTAT00070064524.1

    2. XM_005207036.5 → XP_005207093.1  NKG2-D type II integral membrane protein isoform X1

      See identical proteins and their annotated locations for XP_005207093.1

      UniProtKB/TrEMBL
      A0A3Q1NI22, F1MI53
      Conserved Domains (1) summary
      cd03593
      Location:85 → 199
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    Nucleotide Protein Strain
    Heading Accession and Version

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