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    CD38 CD38 molecule [ Bos taurus (domestic cattle) ]

    Gene ID: 327677, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CD38provided by VGNC
    Official Full Name
    CD38 moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:27027
    See related
    BGD:BT15890; Ensembl:ENSBTAG00000013569
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CD38 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (110986595..111054453)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene bone marrow stromal cell antigen 1 Neighboring gene fibroblast growth factor binding protein 1 Neighboring gene U6 spliceosomal RNA Neighboring gene prominin 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates. Egea PF, et al. PLoS One, 2012. PMID 22529956, Free PMC Article
    2. CD38 in bovine lung: A multicatalytic NADase. Polzonetti V, et al. J Membr Biol, 2009 Feb. PMID 19169615
    3. Formation and function of ceramide-enriched membrane platforms with CD38 during M1-receptor stimulation in bovine coronary arterial myocytes. Jia SJ, et al. Am J Physiol Heart Circ Physiol, 2008 Oct. PMID 18723763, Free PMC Article
    4. Molecular cloning and functional expression of bovine spleen ecto-NAD+ glycohydrolase: structural identity with human CD38. Augustin A, et al. Biochem J, 2000 Jan 1. PMID 10600637, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A detailed analysis is used to propose a catalytic mechanism for bovine CD38/NAD+glycohydrolase.
      Title: Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.
    2. CD38 purified from bovine lung microsomal membranes is a multicatalytic NADase that involved in the regulation of both NAD(+) and calcium-mobilizing agents.
      Title: CD38 in bovine lung: A multicatalytic NADase.
    3. Report the formation and function of ceramide-enriched membrane platforms with CD38 during M1 muscarinic receptor stimulation in bovine coronary arterial myocytes.
      Title: Formation and function of ceramide-enriched membrane platforms with CD38 during M1-receptor stimulation in bovine coronary arterial myocytes.
    4. Report the formation and function of ceramide-enriched membrane platforms with CD38 during M1-receptor stimulation in bovine coronary arterial myocytes.
      Title: Formation and function of ceramide-enriched membrane platforms with CD38 during M1-receptor stimulation in bovine coronary arterial myocytes.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NAD+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
    Names
    ADP-ribosyl cyclase 1
    CD38 antigen
    NP_786992.1
    XP_005208367.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175798.3 → NP_786992.1  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

      See identical proteins and their annotated locations for NP_786992.1

      Status: PROVISIONAL

      Source sequence(s)
      BC126708
      UniProtKB/TrEMBL
      A0A3Q1LJV2, Q9TTF5
      Related
      ENSBTAP00000018042.5, ENSBTAT00000018042.6
      Conserved Domains (1) summary
      pfam02267
      Location:48 → 274
      Rib_hydrolayse; ADP-ribosyl cyclase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      110986595..111054453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005208310.5 → XP_005208367.1  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LJV2, A0A3Q1N5J2
      Related
      ENSBTAP00000065471.1, ENSBTAT00000073897.2
      Conserved Domains (1) summary
      pfam02267
      Location:48 → 270
      Rib_hydrolayse; ADP-ribosyl cyclase
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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