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    KPNA7 karyopherin subunit alpha 7 [ Bos taurus (domestic cattle) ]

    Gene ID: 789280, updated on 27-Dec-2024

    Summary

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    Official Symbol
    KPNA7provided by VGNC
    Official Full Name
    karyopherin subunit alpha 7provided by VGNC
    Primary source
    VGNC:VGNC:30706
    See related
    BGD:BT24832; Ensembl:ENSBTAG00000015737
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See KPNA7 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (37123013..37150162)

    Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101904992 Neighboring gene actin related protein 2/3 complex subunit 1A Neighboring gene myosin heavy chain 16 pseudogene Neighboring gene SMAD specific E3 ubiquitin protein ligase 1 Neighboring gene transformation/transcription domain associated protein Neighboring gene small nucleolar RNA ZL1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Bovine ephemeral fever rhabdovirus α1 protein has viroporin-like properties and binds importin β1 and importin 7. Joubert DA, et al. J Virol, 2014 Feb. PMID 24257609, Free PMC Article
    2. Role of importin alpha8, a new member of the importin alpha family of nuclear transport proteins, in early embryonic development in cattle. Tejomurtula J, et al. Biol Reprod, 2009 Aug. PMID 19420384
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bovine ephemeral fever rhabdovirus alpha1 protein binds bovin importin beta1 and importin 7.
      Title: Bovine ephemeral fever rhabdovirus α1 protein has viroporin-like properties and binds importin β1 and importin 7.
    2. KPNA7: mRNA specifically expressed in ovary & mature oocyte; protein high in oocyte & early embryo but low in blastocyst; strong binding affinity for nucleoplasmin 2; KPNA7 knockdown in early embryos decreases embryo development; DNA & AA sequences
      Title: Role of importin alpha8, a new member of the importin alpha family of nuclear transport proteins, in early embryonic development in cattle.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear localization sequence binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    importin subunit alpha-8
    Names
    importin alpha 8
    karyopherin 7
    karyopherin alpha 7 (importin alpha 8)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163947.1 → NP_001157419.1  importin subunit alpha-8

      See identical proteins and their annotated locations for NP_001157419.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000025
      UniProtKB/Swiss-Prot
      C1JZ66, F1MPD2
      UniProtKB/TrEMBL
      A0AAA9TTK1
      Related
      ENSBTAP00000020894.5, ENSBTAT00000020894.6
      Conserved Domains (5) summary
      COG5064
      Location:7 → 488
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:105 → 225
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:7 → 89
      IBB; Importin beta binding domain
      pfam16186
      Location:445 → 488
      Arm_3; Atypical Arm repeat
      sd00043
      Location:240 → 265
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      37123013..37150162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C1JZ66.2 GenPept UniProtKB/Swiss-Prot:C1JZ66

    Gene LinkOut

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    Research Materials