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    ERAP2 endoplasmic reticulum aminopeptidase 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 513572, updated on 29-Jan-2025

    Summary

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    Official Symbol
    ERAP2provided by VGNC
    Official Full Name
    endoplasmic reticulum aminopeptidase 2provided by VGNC
    Primary source
    VGNC:VGNC:28561
    See related
    BGD:BT13658; Ensembl:ENSBTAG00000039275
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human all
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    Genomic context

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    See ERAP2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (96304261..96357081)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene calpastatin Neighboring gene uncharacterized LOC132345826 Neighboring gene endoplasmic reticulum aminopeptidase 1 Neighboring gene leucyl and cystinyl aminopeptidase Neighboring gene FUN14 domain-containing protein 1-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peptide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    endoplasmic reticulum aminopeptidase 2
    Names
    leukocyte-derived arginine aminopeptidase
    NP_001069096.2
    XP_005209817.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075628.2 → NP_001069096.2  endoplasmic reticulum aminopeptidase 2 precursor

      See identical proteins and their annotated locations for NP_001069096.2

      Status: PROVISIONAL

      Source sequence(s)
      BC149475
      UniProtKB/Swiss-Prot
      A6QPT7
      UniProtKB/TrEMBL
      A0AAF6YHD2
      Conserved Domains (3) summary
      cd09601
      Location:70 → 542
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:62 → 452
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:615 → 931
      ERAP1_C; ERAP1-like C-terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      96304261..96357081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005209760.5 → XP_005209817.1  endoplasmic reticulum aminopeptidase 2 isoform X1

      See identical proteins and their annotated locations for XP_005209817.1

      UniProtKB/Swiss-Prot
      A6QPT7
      UniProtKB/TrEMBL
      A0AAF6YHD2
      Related
      ENSBTAP00070000388.1, ENSBTAT00070000656.1
      Conserved Domains (3) summary
      cd09601
      Location:70 → 542
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:62 → 452
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:615 → 931
      ERAP1_C; ERAP1-like C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6QPT7.1 GenPept UniProtKB/Swiss-Prot:A6QPT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.