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    D2HGDH D-2-hydroxyglutarate dehydrogenase [ Bos taurus (domestic cattle) ]

    Gene ID: 533003, updated on 27-Dec-2024

    Summary

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    Official Symbol
    D2HGDHprovided by VGNC
    Official Full Name
    D-2-hydroxyglutarate dehydrogenaseprovided by VGNC
    Primary source
    VGNC:VGNC:27861
    See related
    BGD:BT24808; Ensembl:ENSBTAG00000002847
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    D2HGD
    Orthologs
    human mouse all
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    Genomic context

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    See D2HGDH in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (120765589..120791784)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene deoxythymidylate kinase Neighboring gene inhibitor of growth family member 5 Neighboring gene galactose-3-O-sulfotransferase 2 Neighboring gene neuraminidase 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D-2-hydroxyglutarate dehydrogenase, mitochondrial
    NP_001069446.1
    XP_005205097.1
    XP_005205098.1
    XP_010802205.1
    XP_024845205.1
    XP_059740649.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075978.1 → NP_001069446.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001069446.1

      Status: PROVISIONAL

      Source sequence(s)
      BT025420
      UniProtKB/Swiss-Prot
      Q1JPD3
      Conserved Domains (3) summary
      COG0277
      Location:92 → 542
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:124 → 261
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:298 → 538
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      120765589..120791784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005205041.5 → XP_005205098.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005205098.1

      UniProtKB/Swiss-Prot
      A5PKH4, Q1JPD3
      Conserved Domains (3) summary
      COG0277
      Location:92 → 542
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:124 → 261
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:298 → 538
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    2. XM_010803903.4 → XP_010802205.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_010802205.1

      UniProtKB/Swiss-Prot
      A5PKH4, Q1JPD3
      Conserved Domains (3) summary
      COG0277
      Location:92 → 542
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:124 → 261
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:298 → 538
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    3. XM_005205040.4 → XP_005205097.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005205097.1

      UniProtKB/Swiss-Prot
      A5PKH4, Q1JPD3
      Related
      ENSBTAP00000003690.4, ENSBTAT00000003690.6
      Conserved Domains (3) summary
      COG0277
      Location:92 → 542
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:124 → 261
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:298 → 538
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    4. XM_059884666.1 → XP_059740649.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X2

    5. XM_024989437.2 → XP_024845205.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X2

      Conserved Domains (1) summary
      COG0277
      Location:2 → 385
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1JPD3.2 GenPept UniProtKB/Swiss-Prot:Q1JPD3

    Gene LinkOut

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