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    FKBP14 FKBP prolyl isomerase 14 [ Bos taurus (domestic cattle) ]

    Gene ID: 615718, updated on 29-Jan-2025

    Summary

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    Official Symbol
    FKBP14provided by VGNC
    Official Full Name
    FKBP prolyl isomerase 14provided by VGNC
    Primary source
    VGNC:VGNC:29019
    See related
    BGD:BT24216; Ensembl:ENSBTAG00000007870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See FKBP14 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (66328674..66340718)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene maturin, neural progenitor differentiation regulator homolog Neighboring gene pleckstrin homology domain containing A8 Neighboring gene secernin 1 Neighboring gene WAS/WASL interacting protein family member 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP14
    Names
    FK506 binding protein 14, 22 kDa
    NP_001069859.2
    XP_005205563.1
    XP_059741735.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076391.4 → NP_001069859.2  peptidyl-prolyl cis-trans isomerase FKBP14 precursor

      See identical proteins and their annotated locations for NP_001069859.2

      Status: VALIDATED

      Source sequence(s)
      NKLS02000004
      UniProtKB/TrEMBL
      F1N4S5
      Related
      ENSBTAP00070040566.1, ENSBTAT00070066542.1
      Conserved Domains (2) summary
      COG0545
      Location:43 → 135
      FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
      pfam13499
      Location:141 → 204
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      66328674..66340718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005205506.5 → XP_005205563.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LWI1
      Related
      ENSBTAP00070040554.1, ENSBTAT00070066528.1
      Conserved Domains (3) summary
      pfam00254
      Location:38 → 117
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:195 → 258
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:196 → 258
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. XM_059885752.1 → XP_059741735.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MTP0
      Related
      ENSBTAP00070040528.1, ENSBTAT00070066495.1

    RNA

    1. XR_234313.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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