U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 327667, updated on 1-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    CACNB2provided by VGNC
    Official Full Name
    calcium voltage-gated channel auxiliary subunit beta 2provided by VGNC
    Primary source
    VGNC:VGNC:26684
    See related
    BGD:BT28775; Ensembl:ENSBTAG00000022000
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CACNB2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (32568577..32994526)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene mannose receptor C-type 1 Neighboring gene solute carrier family 39 member 12 Neighboring gene NOP2/Sun RNA methyltransferase 6 Neighboring gene enhancer of polycomb homolog 1 Neighboring gene kinesin family member 5B

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Coexpression of cloned alpha(1B), beta(2a), and alpha(2)/delta subunits produces non-inactivating calcium currents similar to those found in bovine chromaffin cells. Cahill AL, et al. J Neurosci, 2000 Mar 1. PMID 10684870, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    voltage-dependent L-type calcium channel subunit beta-2
    Names
    CAB2
    calcium channel voltage-dependent subunit beta 2
    calcium channel, voltage-dependent, beta 2 subunit

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175789.2 → NP_786983.1  voltage-dependent L-type calcium channel subunit beta-2

      Status: PROVISIONAL

      Source sequence(s)
      AF174417
      UniProtKB/Swiss-Prot
      Q9MZL5
      UniProtKB/TrEMBL
      A0A3Q1MBH6
      Related
      ENSBTAP00000029344.3, ENSBTAT00000029344.4
      Conserved Domains (4) summary
      cd12040
      Location:57 → 125
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam00625
      Location:225 → 405
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:17 → 58
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:235 → 406
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      32568577..32994526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059892406.1 → XP_059748389.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X8

    2. XM_005214152.5 → XP_005214209.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X3

      UniProtKB/TrEMBL
      Q9MZL4
      Conserved Domains (4) summary
      cd12040
      Location:112 → 180
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam00625
      Location:242 → 422
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:72 → 113
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:252 → 423
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    3. XM_005214150.5 → XP_005214207.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TW09, Q9MZL4
      Related
      ENSBTAP00000101362.1, ENSBTAT00000110321.1
      Conserved Domains (4) summary
      cd12040
      Location:112 → 180
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam00625
      Location:280 → 460
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:72 → 113
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:290 → 461
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    4. XM_005214151.5 → XP_005214208.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X2

      UniProtKB/TrEMBL
      A0AAA9T5M7, Q9MZL4
      Related
      ENSBTAP00000091867.1, ENSBTAT00000115334.1
      Conserved Domains (4) summary
      cd12040
      Location:84 → 152
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam00625
      Location:252 → 432
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:44 → 85
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:262 → 433
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    5. XM_010811102.4 → XP_010809404.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MA95, A0A3Q1MK14
      Related
      ENSBTAP00000069538.1, ENSBTAT00000071974.2
      Conserved Domains (4) summary
      cd12040
      Location:68 → 136
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam00625
      Location:236 → 416
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:28 → 69
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:246 → 417
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    6. XM_005214154.5 → XP_005214211.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1MA95, A0AAA9RZP0
      Related
      ENSBTAP00000078121.1, ENSBTAT00000122827.1
      Conserved Domains (4) summary
      cd12040
      Location:58 → 126
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam00625
      Location:226 → 406
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:18 → 59
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:236 → 407
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    7. XM_059892404.1 → XP_059748387.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X7

      UniProtKB/TrEMBL
      A0A3Q1MA95, A0AAA9T2S9
      Related
      ENSBTAP00000090944.1, ENSBTAT00000122055.1

    8. XM_005214153.5 → XP_005214210.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1LVX8, A0A3Q1MA95
      Related
      ENSBTAP00000061585.1, ENSBTAT00000082900.2
      Conserved Domains (4) summary
      cd12040
      Location:64 → 132
      SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
      pfam00625
      Location:232 → 412
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:24 → 65
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:242 → 413
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MZL5.1 GenPept UniProtKB/Swiss-Prot:Q9MZL5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.