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    WASL WASP like actin nucleation promoting factor [ Bos taurus (domestic cattle) ]

    Gene ID: 281577, updated on 29-Jan-2025

    Summary

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    Official Symbol
    WASLprovided by VGNC
    Official Full Name
    WASP like actin nucleation promoting factorprovided by VGNC
    Primary source
    VGNC:VGNC:56336
    See related
    BGD:BT10329; Ensembl:ENSBTAG00000004643
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See WASL in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (87988369..88070047, complement)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box containing 15 Neighboring gene leiomodin 2 Neighboring gene small nucleolar RNA U3 Neighboring gene hyaluronidase 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Processive acceleration of actin barbed-end assembly by N-WASP. Khanduja N, et al. Mol Biol Cell, 2014 Jan. PMID 24227886, Free PMC Article
    2. N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases. Miki H, et al. EMBO J, 1996 Oct 1. PMID 8895577, Free PMC Article
    3. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate. Rohatgi R, et al. J Cell Biol, 2000 Sep 18. PMID 10995436, Free PMC Article
    4. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Rohatgi R, et al. Cell, 1999 Apr 16. PMID 10219243
    5. Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions. Egile C, et al. PLoS Biol, 2005 Nov. PMID 16262445, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    actin nucleation-promoting factor WASL
    Names
    N-WASP
    Wiskott-Aldrich syndrome like
    neural Wiskott-Aldrich syndrome protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174219.2 → NP_776644.1  actin nucleation-promoting factor WASL

      See identical proteins and their annotated locations for NP_776644.1

      Status: PROVISIONAL

      Source sequence(s)
      D67066
      UniProtKB/Swiss-Prot
      Q95107
      UniProtKB/TrEMBL
      B0JYR3
      Related
      ENSBTAP00070040506.1, ENSBTAT00070066468.1
      Conserved Domains (4) summary
      smart00246
      Location:433 → 450
      WH2; Wiskott Aldrich syndrome homology region 2
      cd01205
      Location:40 → 138
      EVH1_WASP-like; WASP family proteins EVH1 domain
      pfam00786
      Location:202 → 258
      PBD; P21-Rho-binding domain
      pfam02205
      Location:402 → 425
      WH2; WH2 motif

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      87988369..88070047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010804401.3 → XP_010802703.1  actin nucleation-promoting factor WASL isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M352, B0JYR3
      Related
      ENSBTAP00070040477.1, ENSBTAT00070066424.1
      Conserved Domains (4) summary
      smart00246
      Location:439 → 456
      WH2; Wiskott Aldrich syndrome homology region 2
      cd01205
      Location:40 → 138
      EVH1_WASP-like; WASP family proteins EVH1 domain
      pfam00786
      Location:202 → 259
      PBD; P21-Rho-binding domain
      pfam02205
      Location:408 → 431
      WH2; WH2 motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95107.1 GenPept UniProtKB/Swiss-Prot:Q95107

    Gene LinkOut

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