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    NKRF NFKB repressing factor [ Bos taurus (domestic cattle) ]

    Gene ID: 100124519, updated on 29-Jan-2025

    Summary

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    Official Symbol
    NKRFprovided by VGNC
    Official Full Name
    NFKB repressing factorprovided by VGNC
    Primary source
    VGNC:VGNC:52805
    See related
    Ensembl:ENSBTAG00000045744
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NKRF in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (3945040..3961596, complement)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 5 Neighboring gene STING1 ER exit protein 1 Neighboring gene ubiquitin conjugating enzyme E2 A Neighboring gene septin 6 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene sosondowah ankyrin repeat domain family member D

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Bta-miR-101 suppresses BEFV replication via targeting NKRF. Zhao W, et al. Vet Microbiol, 2021 Aug. PMID 34058703
    2. The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha. Sorriento D, et al. Proc Natl Acad Sci U S A, 2008 Nov 18. PMID 19008357, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bta-miR-101 suppresses BEFV replication via targeting NKRF.
      Title: Bta-miR-101 suppresses BEFV replication via targeting NKRF.
    2. GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.
      Title: The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC137773

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NF-kappa-B-repressing factor
    Names
    NF-kappaB repressing factor
    transcription factor NRF

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102553.1 → NP_001096023.1  NF-kappa-B-repressing factor

      See identical proteins and their annotated locations for NP_001096023.1

      Status: PROVISIONAL

      Source sequence(s)
      BC114697
      UniProtKB/TrEMBL
      A4FUC4
      Conserved Domains (3) summary
      cd02640
      Location:603 → 662
      R3H_NRF; R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB proteins that can silence the IFNbeta promoter via binding to a negative regulatory element (NRE). Beside R3H NRF also contains a G-patch domain. The name of the ...
      smart00358
      Location:349 → 410
      DSRM; Double-stranded RNA binding motif
      cl02611
      Location:549 → 592
      G-patch; G-patch domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      3945040..3961596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005227427.5 → XP_005227484.2  NF-kappa-B-repressing factor isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MAF5
      Related
      ENSBTAP00070034533.1, ENSBTAT00070058067.1
      Conserved Domains (4) summary
      cd02640
      Location:697 → 756
      R3H_NRF; R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB proteins that can silence the IFNbeta promoter via binding to a negative regulatory element (NRE). Beside R3H NRF also contains a G-patch domain. The name of the ...
      smart00358
      Location:443 → 504
      DSRM; Double-stranded RNA binding motif
      pfam11952
      Location:38 → 105
      XTBD; XRN-Two Binding Domain, XTBD
      cl02611
      Location:643 → 686
      G-patch; G-patch domain

    2. XM_005227428.5 → XP_005227485.2  NF-kappa-B-repressing factor isoform X1

      UniProtKB/TrEMBL
      G3MYW2
      Related
      ENSBTAP00070034526.1, ENSBTAT00070058057.1
      Conserved Domains (4) summary
      cd02640
      Location:730 → 789
      R3H_NRF; R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB proteins that can silence the IFNbeta promoter via binding to a negative regulatory element (NRE). Beside R3H NRF also contains a G-patch domain. The name of the ...
      smart00358
      Location:476 → 537
      DSRM; Double-stranded RNA binding motif
      pfam11952
      Location:38 → 138
      XTBD; XRN-Two Binding Domain, XTBD
      cl02611
      Location:676 → 719
      G-patch; G-patch domain
    Nucleotide Protein Strain
    Heading Accession and Version

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