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    URAH urate (hydroxyiso-) hydrolase [ Bos taurus (domestic cattle) ]

    Gene ID: 100296324, updated on 27-Dec-2024

    Summary

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    Official Symbol
    URAHprovided by VGNC
    Official Full Name
    urate (hydroxyiso-) hydrolaseprovided by VGNC
    Primary source
    VGNC:VGNC:108955
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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    Genomic context

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    See URAH in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (14792434..14795316, complement)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene AFG3-like protein 1 Neighboring gene dysbindin domain containing 1 Neighboring gene growth arrest specific 8 Neighboring gene uncharacterized LOC112442447 Neighboring gene SHC binding and spindle associated 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hydroxyisourate hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in purine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5-hydroxyisourate hydrolase
    XP_002694914.2
    XP_010812904.1
    XP_059733389.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      14792434..14795316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010814602.4 → XP_010812904.1  5-hydroxyisourate hydrolase isoform X1

      See identical proteins and their annotated locations for XP_010812904.1

      Conserved Domains (1) summary
      cd05822
      Location:29 → 141
      TLP_HIUase; HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). ...

    2. XM_002694868.7 → XP_002694914.2  5-hydroxyisourate hydrolase isoform X1

      See identical proteins and their annotated locations for XP_002694914.2

      Conserved Domains (1) summary
      cd05822
      Location:29 → 141
      TLP_HIUase; HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). ...

    3. XM_059877406.1 → XP_059733389.1  5-hydroxyisourate hydrolase isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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