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    SLC8A1 solute carrier family 8 member A1 [ Bos taurus (domestic cattle) ]

    Gene ID: 337925, updated on 27-Dec-2024

    Summary

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    Official Symbol
    SLC8A1provided by VGNC
    Official Full Name
    solute carrier family 8 member A1provided by VGNC
    Primary source
    VGNC:VGNC:34935
    See related
    BGD:BT10977; Ensembl:ENSBTAG00000013861
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    NCX1
    Orthologs
    human mouse all
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    Genomic context

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    See SLC8A1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (22407415..22854939, complement)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346510 Neighboring gene hsc70-interacting protein-like Neighboring gene uncharacterized LOC112448760 Neighboring gene uncharacterized LOC104973311 Neighboring gene uncharacterized LOC132346511 Neighboring gene large ribosomal subunit protein eL36-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Optimal metabolic regulation of the mammalian heart Na(+)/Ca(2+) exchanger requires a spacial arrangements with a PtdIns(4)-5kinase. Forcato D, et al. Biochem Biophys Res Commun, 2010 Nov 5. PMID 20933499
    2. Regulation of sodium-calcium exchanger activity by creatine kinase under energy-compromised conditions. Yang YC, et al. J Biol Chem, 2010 Sep 3. PMID 20576602, Free PMC Article
    3. mu-Calpain mediated cleavage of the Na+/Ca2+ exchanger in isolated mitochondria under A23187 induced Ca2+ stimulation. Kar P, et al. Arch Biochem Biophys, 2009 Feb. PMID 19094959
    4. The reverse mode of the Na(+)/Ca(2+) exchanger provides a source of Ca(2+) for store refilling following agonist-induced Ca(2+) mobilization. Hirota S, et al. Am J Physiol Lung Cell Mol Physiol, 2007 Feb. PMID 17041014
    5. Regulation of phosphatidylinositol-4,5-biphosphate bound to the bovine cardiac Na+/Ca2+ exchanger. Beaugé L, et al. Ann N Y Acad Sci, 2002 Nov. PMID 12502572

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that, for a proper MgATP up-regulation of NCX1, the enzyme responsible for PtdIns-4,5P2 synthesis must be (i) functionally competent and (ii) set in the NCX1 microenvironment closely associated to the exchanger.
      Title: Optimal metabolic regulation of the mammalian heart Na(+)/Ca(2+) exchanger requires a spacial arrangements with a PtdIns(4)-5kinase.
    2. The cleavage of NCX1 by m-calpain in the caveolae vesicles may be interpreted as an important mechanism of Ca(2+) overload
      Title: m-Calpain-mediated cleavage of Na+/Ca2+ exchanger-1 in caveolae vesicles isolated from pulmonary artery smooth muscle.
    3. a novel mechanism for the regulation of NCX1 activity
      Title: Regulation of sodium-calcium exchanger activity by creatine kinase under energy-compromised conditions.
    4. Cleavage of NCX may be interpreted as the main cause of Ca(2+) overload and could lay a key role in activation of apoptotic processes in pulmonary smooth muscle.
      Title: mu-Calpain mediated cleavage of the Na+/Ca2+ exchanger in isolated mitochondria under A23187 induced Ca2+ stimulation.
    5. These data suggest a role for the reverse mode of the NCX in refilling the sarcoplasmic reticulum in airway smooth muscle following Ca(2+) mobilization.
      Title: The reverse mode of the Na(+)/Ca(2+) exchanger provides a source of Ca(2+) for store refilling following agonist-induced Ca(2+) mobilization.
    6. Data suggest that peroxynitrite leads to calcium (Ca2+) uptake through stimulation of Ca2+-ATPase, but inhibits Ca2+ uptake through inhibition of the sodium-Ca2+ exchanger, resulting in decreased overall Ca2+ uptake in smooth muscle microsomes.
      Title: Inhibition of Na+/Ca2+ exchanger by peroxynitrite in microsomes of pulmonary smooth muscle: role of matrix metalloproteinase-2.
    7. Na/Ca exchanger's (NCX1) associates specifically with caveolin-3(NCX1)(caveolin-3)
      Title: The cardiac sodium-calcium exchanger associates with caveolin-3.
    8. the regulation of phosphatidylinositol-4,5-biphosphate binding to the bovine cardiac Na+/Ca2+ exchanger(NCX1)
      Title: Regulation of phosphatidylinositol-4,5-biphosphate bound to the bovine cardiac Na+/Ca2+ exchanger.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium:sodium antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sodium/calcium exchanger 1
    Names
    Na(+)/Ca(2+)-exchange protein 1
    sodium-calcium exchanger
    solute carrier family 8, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176632.2 → NP_788805.1  sodium/calcium exchanger 1 precursor

      See identical proteins and their annotated locations for NP_788805.1

      Status: PROVISIONAL

      Source sequence(s)
      L06438
      UniProtKB/Swiss-Prot
      P48765
      UniProtKB/TrEMBL
      A0AAA9TB21
      Conserved Domains (5) summary
      smart00237
      Location:534 → 624
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:1 → 970
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:797 → 961
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03160
      Location:403 → 493
      Calx-beta; Calx-beta domain
      pfam16494
      Location:251 → 381
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      22407415..22854939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005212561.5 → XP_005212618.1  sodium/calcium exchanger 1 isoform X2

      UniProtKB/TrEMBL
      F1MC36
      Conserved Domains (5) summary
      smart00237
      Location:555 → 645
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:22 → 991
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:818 → 982
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03160
      Location:424 → 514
      Calx-beta; Calx-beta domain
      pfam16494
      Location:272 → 402
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    2. XM_010809914.4 → XP_010808216.1  sodium/calcium exchanger 1 isoform X6

      See identical proteins and their annotated locations for XP_010808216.1

      UniProtKB/TrEMBL
      A0AAA9TB21
      Conserved Domains (5) summary
      smart00237
      Location:534 → 624
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:1 → 970
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:797 → 961
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03160
      Location:403 → 493
      Calx-beta; Calx-beta domain
      pfam16494
      Location:251 → 381
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    3. XM_024998355.2 → XP_024854123.1  sodium/calcium exchanger 1 isoform X9

      UniProtKB/TrEMBL
      F1MC36, F6R8D6
      Related
      ENSBTAP00000018452.5, ENSBTAT00000018452.6
      Conserved Domains (1) summary
      TIGR00845
      Location:25 → 958
      caca; sodium/calcium exchanger 1

    4. XM_024998352.2 → XP_024854120.1  sodium/calcium exchanger 1 isoform X4

      UniProtKB/TrEMBL
      F1MC36
      Conserved Domains (1) summary
      TIGR00845
      Location:25 → 986
      caca; sodium/calcium exchanger 1

    5. XM_024998354.2 → XP_024854122.1  sodium/calcium exchanger 1 isoform X8

      UniProtKB/TrEMBL
      F1MC36
      Conserved Domains (1) summary
      TIGR00845
      Location:25 → 959
      caca; sodium/calcium exchanger 1

    6. XM_024998351.2 → XP_024854119.1  sodium/calcium exchanger 1 isoform X3

      UniProtKB/TrEMBL
      F1MC36
      Conserved Domains (1) summary
      TIGR00845
      Location:25 → 987
      caca; sodium/calcium exchanger 1

    7. XM_024998353.2 → XP_024854121.1  sodium/calcium exchanger 1 isoform X7

      UniProtKB/TrEMBL
      F1MC36
      Conserved Domains (1) summary
      TIGR00845
      Location:25 → 966
      caca; sodium/calcium exchanger 1

    8. XM_059891028.1 → XP_059747011.1  sodium/calcium exchanger 1 isoform X5

      UniProtKB/TrEMBL
      F1MC36

    9. XM_005212560.5 → XP_005212617.1  sodium/calcium exchanger 1 isoform X1

      See identical proteins and their annotated locations for XP_005212617.1

      UniProtKB/TrEMBL
      F1MC36
      Conserved Domains (5) summary
      smart00237
      Location:558 → 648
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:25 → 994
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:821 → 985
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03160
      Location:427 → 517
      Calx-beta; Calx-beta domain
      pfam16494
      Location:275 → 405
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    10. XM_059891027.1 → XP_059747010.1  sodium/calcium exchanger 1 isoform X1

      UniProtKB/TrEMBL
      F1MC36

    11. XM_005212559.5 → XP_005212616.1  sodium/calcium exchanger 1 isoform X1

      See identical proteins and their annotated locations for XP_005212616.1

      UniProtKB/TrEMBL
      F1MC36
      Conserved Domains (5) summary
      smart00237
      Location:558 → 648
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:25 → 994
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:821 → 985
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03160
      Location:427 → 517
      Calx-beta; Calx-beta domain
      pfam16494
      Location:275 → 405
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    12. XM_015473427.3 → XP_015328913.1  sodium/calcium exchanger 1 isoform X6

      UniProtKB/TrEMBL
      A0AAA9TB21
      Conserved Domains (5) summary
      smart00237
      Location:534 → 624
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:1 → 970
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:797 → 961
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03160
      Location:403 → 493
      Calx-beta; Calx-beta domain
      pfam16494
      Location:251 → 381
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    13. XM_015473425.3 → XP_015328911.1  sodium/calcium exchanger 1 isoform X6

      UniProtKB/TrEMBL
      A0AAA9TB21
      Conserved Domains (5) summary
      smart00237
      Location:534 → 624
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:1 → 970
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:797 → 961
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03160
      Location:403 → 493
      Calx-beta; Calx-beta domain
      pfam16494
      Location:251 → 381
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    14. XM_015473426.3 → XP_015328912.1  sodium/calcium exchanger 1 isoform X6

      UniProtKB/TrEMBL
      A0AAA9TB21
      Conserved Domains (5) summary
      smart00237
      Location:534 → 624
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:1 → 970
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:797 → 961
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03160
      Location:403 → 493
      Calx-beta; Calx-beta domain
      pfam16494
      Location:251 → 381
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48765.1 GenPept UniProtKB/Swiss-Prot:P48765

    Gene LinkOut

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