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    ACAN aggrecan [ Bos taurus (domestic cattle) ]

    Gene ID: 280985, updated on 1-Jan-2025

    Summary

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    Official Symbol
    ACANprovided by VGNC
    Official Full Name
    aggrecanprovided by VGNC
    Primary source
    VGNC:VGNC:25525
    See related
    Ensembl:ENSBTAG00000016158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    AGC1
    Orthologs
    human mouse all
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    Genomic context

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    See ACAN in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (20377694..20447099)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene myeloid-associated differentiation marker-like Neighboring gene myeloid-associated differentiation marker Neighboring gene uncharacterized LOC132343337 Neighboring gene hyaluronan and proteoglycan link protein 3 Neighboring gene milk fat globule EGF and factor V/VIII domain containing

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Distribution of newly synthesized aggrecan in explant cultures of bovine cartilage treated with retinoic acid. Handley CJ, et al. Matrix Biol, 2002 Nov. PMID 12475642
    2. Characterization of the bovine aggrecan gene: genomic structure and physical and linkage mapping. Cavanagh JA, et al. Anim Genet, 2005 Oct. PMID 16167996
    3. Structural relationship between link proteins and proteoglycan monomers. Périn JP, et al. FEBS Lett, 1986 Sep 29. PMID 3530809
    4. Bulldog dwarfism in Dexter cattle is caused by mutations in ACAN. Cavanagh JA, et al. Mamm Genome, 2007 Nov. PMID 17952705
    5. Aggrecan protects cartilage collagen from proteolytic cleavage. Pratta MA, et al. J Biol Chem, 2003 Nov 14. PMID 12890681

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural changes in collagen and aggrecan during extended aging may improve beef tenderness.
      Title: Structural changes in collagen and aggrecan during extended aging may improve beef tenderness.
    2. the subsequent presentation of aggregan from ECM leads to CD4(+) T-cell activation and effector cell formation.
      Title: Antigen-specific B lymphocytes acquire proteoglycan aggrecan from cartilage extracellular matrix resulting in antigen presentation and CD4+ T-cell activation.
    3. Data show that expression of mRNAs for aggrecan, collagen type II, and versican were significantly effected by the intervention.
      Title: Disc strain and resulting positive mRNA expression from application of a noninvasive treatment.
    4. The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase) explains the minor contribution of the MMP enzymes to aggrecan catabolism in vivo.
      Title: MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein.
    5. Self-adhesion between highly negatively charged aggrecan macromolecules extracted from bovine cartilage extracellular matrix, was investigated.
      Title: Single-molecule force spectroscopy of cartilage aggrecan self-adhesion.
    6. aggrecanase activity (a) is responsible for early TNFalpha-dependent aggrecan cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.
      Title: Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro.
    7. The objective of this study was to compare patterns of aggrecan processing by chondrocytes and meniscal fibrochondrocytes in tissue explants and cell-agarose constructs.
      Title: Chondrocytes and meniscal fibrochondrocytes differentially process aggrecan during de novo extracellular matrix assembly.
    8. identified multiple conserved amino acids within regions N- and C-terminal of aggrecan to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5
      Title: Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5.
    9. Homozygosity mapping in candidate regions in a small Dexter pedigree suggested aggrecan as the most likely candidate gene. Mutation screening revealed a 4-bp insertion in exon 11 (2266_2267insGGCA) and a second, rarer transition in exon 1 (-198C>T).
      Title: Bulldog dwarfism in Dexter cattle is caused by mutations in ACAN.
    10. aggrecan plays a protective role in preventing degradation of collagen fibrils
      Title: Aggrecan protects cartilage collagen from proteolytic cleavage.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in skeletal system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in perineuronal net IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aggrecan core protein
    Names
    CSPCP
    aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122)
    aggrecan epidermal growth factor-like domain-1
    cartilage-specific proteoglycan core protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173981.3 → NP_776406.2  aggrecan core protein precursor

      Status: VALIDATED

      Source sequence(s)
      NKLS02000021
      Related
      ENSBTAP00000021514.4, ENSBTAT00000021514.5

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      20377694..20447099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059878937.1 → XP_059734920.1  aggrecan core protein isoform X1

      UniProtKB/TrEMBL
      Q6XL67

    2. XM_059878938.1 → XP_059734921.1  aggrecan core protein isoform X3

      UniProtKB/Swiss-Prot
      P13608, P79117, Q28159, Q6XL66

    3. XM_059878939.1 → XP_059734922.1  aggrecan core protein isoform X4

      UniProtKB/TrEMBL
      Q6XL67

    4. XM_024981588.2 → XP_024837356.1  aggrecan core protein isoform X2

      UniProtKB/TrEMBL
      F1N368, Q6XL67
      Related
      ENSBTAP00000021512.5, ENSBTAT00000021512.7
      Conserved Domains (10) summary
      cd05900
      Location:43 → 154
      Ig_Aggrecan; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan
      cd00033
      Location:2283 → 2339
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03588
      Location:2156 → 2279
      CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins
      cd00054
      Location:2114 → 2150
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:153 → 247
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:254 → 349
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      cl25495
      Location:1926 → 2064
      Endomucin; Endomucin
      cl25496
      Location:1823 → 2110
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl26018
      Location:1162 → 1333
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26464
      Location:686 → 971
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13608.3 GenPept UniProtKB/Swiss-Prot:P13608

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials