IGF2 insulin like growth factor 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: IGF2provided by VGNC
Official Full Name: insulin like growth factor 2provided by VGNC
Primary source: VGNC:VGNC:30078
See related: BGD:BT11333; Ensembl:ENSBTAG00000013066
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Summary: This gene encodes a member of the insulin family of protein growth factors, which are involved in fetal development and growth. It is an imprinted gene that is expressed from the paternal allele while the maternal allele is silenced. The encoded protein is proteolytically processed to generate the mature peptide hormone, which binds to receptors of the insulin receptor family. This peptide plays a role in oocyte development and folliculogenesis in female cattle. Polymorphisms in this gene may be associated with cattle body mass. [provided by RefSeq, Dec 2018]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 29

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	29	NC_037356.1 (49395153..49422472)

Chromosome 29 - NC_037356.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
Title: Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
Methylation pattern in a CpG island of the IGF2 gene in cumulus cells from 1-3 mm and >/= 8.0 mm follicles and the effects of in vitro maturation on this pattern.
Title: Characterisation of the methylation pattern in the intragenic CpG island of the IGF2 gene in Bos taurus indicus cumulus cells during in vitro maturation.
Our results provide evidence that polymorphisms in the IGF2 gene are associated with growth traits, and may be used for marker-assisted selection in beef cattle breeding program
Title: SNP and haplotype analysis reveal IGF2 variants associated with growth traits in Chinese Qinchuan cattle.
The identification of the polymorphisms in the IGF2 gene that were significantly associated with growth traits in cattle.
Title: Comparative analysis of the IGF2 and ZBED6 gene variants and haplotypes reveals significant effect of growth traits in cattle.
Polymorphisms in the IGF2 gene are associated with cattle growth traits.
Title: Assessment of association between variants and haplotypes of the IGF2 gene in beef cattle.
The LEP, IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.
Title: Allelic gene expression imbalance of bovine IGF2, LEP and CCL2 genes in liver, kidney and pituitary.
Sex-sorting procedure by flow cytometry did not affect the overall DNA methylation patterns of the IGF2 and IGF2R genes, although individual variation in their methylation patterns among bulls was observed.
Title: The methylation patterns of the IGF2 and IGF2R genes in bovine spermatozoa are not affected by flow-cytometric sex sorting.
The reduction in IGFs mRNA level after 5 days of life in the duodenum (IGF-1 and IGF-2) and in the jejunum (IGF-1) was associated with reduction in villi length (duodenum and jejunum) and the increase of crypt depth (duodenum).
Title: Insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) mRNA levels in relation to the gastrointestinal tract (GIT) development in newborn calves.
Changes in the methylation pattern of IGF2 during in vitro maturation were different between incompetent and competent oocytes, and this characteristic may be useful as a molecular marker in studies of oocyte competence in cattle.
Title: Methylation status in the intragenic differentially methylated region of the IGF2 locus in Bos taurus indicus oocytes with different developmental competencies.
Data describes the long-term changes to skeletal muscle growth and IGF1, 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
Title: Protein intake during gestation affects postnatal bovine skeletal muscle growth and relative expression of IGF1, IGF1R, IGF2 and IGF2R.

Submit: New GeneRIF Correction See all GeneRIFs (22)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed
enables insulin-like growth factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of activated T cell proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of glycogen (starch) synthase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of vascular endothelial cell proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of muscle cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor 2

Names: IGF-II; erythrotropin; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001367627.1 → NP_001354556.1 insulin-like growth factor 2 preproprotein

Status: REVIEWED

Source sequence(s)

NKLS02000029

UniProtKB/Swiss-Prot

A0A5F2, P07456, Q2HJN0

UniProtKB/TrEMBL

B8QGI3
NM_001367628.1 → NP_001354557.1 insulin-like growth factor 2 preproprotein

Status: REVIEWED

Source sequence(s)

NKLS02000029

UniProtKB/Swiss-Prot

A0A5F2, P07456, Q2HJN0

UniProtKB/TrEMBL

B8QGI3
NM_001367629.1 → NP_001354558.1 insulin-like growth factor 2 preproprotein

Status: REVIEWED

Source sequence(s)

NKLS02000029

UniProtKB/Swiss-Prot

A0A5F2, P07456, Q2HJN0

UniProtKB/TrEMBL

B8QGI3
NM_001367630.1 → NP_001354559.1 insulin-like growth factor 2 preproprotein

Status: REVIEWED

Source sequence(s)

EE251352, NKLS02000029

UniProtKB/Swiss-Prot

A0A5F2, P07456, Q2HJN0

UniProtKB/TrEMBL

B8QGI3
NM_001367631.1 → NP_001354560.1 insulin-like growth factor 2 preproprotein

Status: REVIEWED

Source sequence(s)

BC116039, NKLS02000029

UniProtKB/Swiss-Prot

A0A5F2, P07456, Q2HJN0

UniProtKB/TrEMBL

B8QGI3
NM_001367632.1 → NP_001354561.1 insulin-like growth factor 2 preproprotein

Status: REVIEWED

Source sequence(s)

NKLS02000029

UniProtKB/Swiss-Prot

A0A5F2, P07456, Q2HJN0

UniProtKB/TrEMBL

B8QGI3
NM_174087.4 → NP_776512.2 insulin-like growth factor 2 preproprotein

See identical proteins and their annotated locations for NP_776512.2

Status: REVIEWED

Source sequence(s)

NKLS02000029

UniProtKB/Swiss-Prot

A0A5F2, P07456, Q2HJN0

UniProtKB/TrEMBL

B8QGI3

Related

ENSBTAP00000017372.5, ENSBTAT00000017372.7

Conserved Domains (2) summary

cd04368
Location:28 → 91

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

pfam08365
Location:112 → 166

IGF2_C; Insulin-like growth factor II E-peptide

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

Range

49395153..49422472

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005227270.5 → XP_005227327.1 insulin-like growth factor 2 isoform X1

See identical proteins and their annotated locations for XP_005227327.1

UniProtKB/TrEMBL

A0AAA9TF33

Related

ENSBTAP00000094753.1, ENSBTAT00000134412.1

Conserved Domains (2) summary

cd04368
Location:84 → 147

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

pfam08365
Location:168 → 222

IGF2_C; Insulin-like growth factor II E-peptide