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    LOC407218 calcitonin-related polypeptide beta [ Bos taurus (domestic cattle) ]

    Gene ID: 407218, updated on 1-Jan-2025

    Summary

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    Gene symbol
    LOC407218
    Gene description
    calcitonin-related polypeptide beta
    See related
    BGD:BT22156; Ensembl:ENSBTAG00000001516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CALCB; CRSP1
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    Genomic context

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    See LOC407218 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (37806135..37809438, complement)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene calcitonin related polypeptide beta Neighboring gene transfer RNA tyrosine (anticodon GUA) Neighboring gene calcitonin-related polypeptide alpha Neighboring gene vacuolar protein sorting-associated protein 33A-like Neighboring gene cytochrome P450 family 2 subfamily R member 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Identification, structural determination, and biological activity of bovine and canine calcitonin receptor-stimulating peptides. Katafuchi T, et al. Biochem Biophys Res Commun, 2004 Jan 2. PMID 14672700
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC142514

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcitonin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcitonin receptor-stimulating peptide 1
    Names
    CRSP-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001149.2 → NP_001001149.1  calcitonin receptor-stimulating peptide 1 isoform b precursor

      See identical proteins and their annotated locations for NP_001001149.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform b which has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AB125101, DV827218
      UniProtKB/Swiss-Prot
      Q17Q98, Q75V95
      Conserved Domains (1) summary
      pfam00214
      Location:1 → 121
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    2. NM_001134662.1 → NP_001128134.1  calcitonin receptor-stimulating peptide 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001128134.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BC118475
      UniProtKB/Swiss-Prot
      Q75V95
      Related
      ENSBTAP00000001987.4, ENSBTAT00000001987.5
      Conserved Domains (1) summary
      pfam00214
      Location:1 → 74
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      37806135..37809438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q75V95.1 GenPept UniProtKB/Swiss-Prot:Q75V95

    Gene LinkOut

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    Research Materials