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    MFAP2 microfibril associated protein 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281912, updated on 29-Jan-2025

    Summary

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    Official Symbol
    MFAP2provided by VGNC
    Official Full Name
    microfibril associated protein 2provided by VGNC
    Primary source
    VGNC:VGNC:31422
    See related
    BGD:BT11288; Ensembl:ENSBTAG00000003832
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MFAP2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (135609074..135615966)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene succinate dehydrogenase complex iron sulfur subunit B Neighboring gene ATPase cation transporting 13A2 Neighboring gene ciliary rootlet coiled-coil, rootletin Neighboring gene NECAP endocytosis associated 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Microfibril-associated glycoprotein: characterization of the bovine gene and of the recombinantly expressed protein. Bashir MM, et al. Biochemistry, 1994 Jan 18. PMID 8286390
    2. Complementary DNA cloning establishes microfibril-associated glycoprotein (MAGP) to be a discrete component of the elastin-associated microfibrils. Gibson MA, et al. J Biol Chem, 1991 Apr 25. PMID 2019589
    3. Posttranslational modifications of microfibril associated glycoprotein-1 (MAGP-1). Trask BC, et al. Biochemistry, 2001 Apr 10. PMID 11284693
    4. MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils. Hanssen E, et al. J Biol Chem, 2004 Jul 9. PMID 15131124
    5. Molecular interactions of biglycan and decorin with elastic fiber components: biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein 1. Reinboth B, et al. J Biol Chem, 2002 Feb 8. PMID 11723132

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in embryonic eye morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in microfibril IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    microfibrillar-associated protein 2
    Names
    MAGP
    MAGP-1
    MFAP-2
    microfibril-associated glycoprotein 1
    microfibrillar associated protein 2
    tropoelastin-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174388.2 → NP_776813.1  microfibrillar-associated protein 2 precursor

      See identical proteins and their annotated locations for NP_776813.1

      Status: PROVISIONAL

      Source sequence(s)
      S68064
      UniProtKB/Swiss-Prot
      P27424
      UniProtKB/TrEMBL
      F1MWK6
      Conserved Domains (1) summary
      pfam05507
      Location:1 → 151
      MAGP; Microfibril-associated glycoprotein (MAGP)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      135609074..135615966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005203074.3 → XP_005203131.1  microfibrillar-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005203131.1

      UniProtKB/TrEMBL
      F1MWK6
      Conserved Domains (1) summary
      pfam05507
      Location:4 → 151
      MAGP; Microfibril-associated glycoprotein (MAGP)

    2. XM_005203073.3 → XP_005203130.1  microfibrillar-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005203130.1

      UniProtKB/TrEMBL
      F1MWK6
      Related
      ENSBTAP00070000030.1, ENSBTAT00070000054.1
      Conserved Domains (1) summary
      pfam05507
      Location:4 → 151
      MAGP; Microfibril-associated glycoprotein (MAGP)

    3. XM_005203076.4 → XP_005203133.1  microfibrillar-associated protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LQL8, F1MWK6
      Related
      ENSBTAP00070000029.1, ENSBTAT00070000053.1
      Conserved Domains (1) summary
      pfam05507
      Location:75 → 150
      MAGP; Microfibril-associated glycoprotein (MAGP)

    4. XM_059891705.1 → XP_059747688.1  microfibrillar-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      F1MWK6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27424.1 GenPept UniProtKB/Swiss-Prot:P27424

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