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    AP2B1 adaptor related protein complex 2 subunit beta 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 282183, updated on 27-Dec-2024

    Summary

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    Official Symbol
    AP2B1provided by VGNC
    Official Full Name
    adaptor related protein complex 2 subunit beta 1provided by VGNC
    Primary source
    VGNC:VGNC:55033
    See related
    BGD:BT11432; Ensembl:ENSBTAG00000020316
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CLAPB1
    Orthologs
    human mouse all
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    Genomic context

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    See AP2B1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (14649514..14763818, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343014 Neighboring gene growth arrest specific 2 like 2 Neighboring gene RAS like family 10 member B Neighboring gene Z30 small nucleolar RNA Neighboring gene peroxisomal biogenesis factor 12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Conservation and diversity in families of coated vesicle adaptins. Ponnambalam S, et al. J Biol Chem, 1990 Mar 25. PMID 1969413
    2. Quantitative analysis of TIP47-receptor cytoplasmic domain interactions: implications for endosome-to-trans Golgi network trafficking. Krise JP, et al. J Biol Chem, 2000 Aug 18. PMID 10829017
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AP-2 complex subunit beta
    Names
    AP-1 complex subunit beta-1
    AP105B
    adapter-related protein complex 1 subunit beta-1
    adapter-related protein complex 2 beta subunit
    adapter-related protein complex 2 subunit beta
    adaptor protein complex AP-1 subunit beta-1
    adaptor protein complex AP-2 subunit beta
    adaptor-related protein complex 1 subunit beta-1
    adaptor-related protein complex 2 subunit beta
    adaptor-related protein complex 2, beta 1 subunit
    beta-1-adaptin
    beta-2-adaptin
    beta-adaptin 1
    beta1-adaptin
    beta2-adaptin
    clathrin assembly protein complex 1 beta large chain
    clathrin assembly protein complex 2 beta large chain
    clathrin-associated / assembly / adaptor protein, large, beta 1
    golgi adaptor HA1/AP1 adaptin beta subunit
    plasma membrane adaptor HA2/AP2 adaptin beta subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075125.2 → NP_001068593.1  AP-2 complex subunit beta

      See identical proteins and their annotated locations for NP_001068593.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123583
      UniProtKB/Swiss-Prot
      Q08DS7
      Related
      ENSBTAP00000060816.1, ENSBTAT00000076585.2
      Conserved Domains (4) summary
      smart00809
      Location:731 → 831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840 → 950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      14649514..14763818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059877728.1 → XP_059733711.1  AP-2 complex subunit beta isoform X2

      UniProtKB/Swiss-Prot
      P63009
      UniProtKB/TrEMBL
      G3X7G4

    2. XM_059877727.1 → XP_059733710.1  AP-2 complex subunit beta isoform X1

      UniProtKB/Swiss-Prot
      Q08DS7

    3. XM_024979626.2 → XP_024835394.1  AP-2 complex subunit beta isoform X2

      UniProtKB/Swiss-Prot
      P63009
      UniProtKB/TrEMBL
      G3X7G4
      Related
      ENSBTAP00000027078.7, ENSBTAT00000027078.7
      Conserved Domains (4) summary
      smart00809
      Location:717 → 817
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:826 → 936
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    4. XM_024979622.2 → XP_024835390.1  AP-2 complex subunit beta isoform X1

      UniProtKB/Swiss-Prot
      Q08DS7
      Conserved Domains (4) summary
      smart00809
      Location:731 → 831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840 → 950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    5. XM_024979621.2 → XP_024835389.1  AP-2 complex subunit beta isoform X1

      UniProtKB/Swiss-Prot
      Q08DS7
      Conserved Domains (4) summary
      smart00809
      Location:731 → 831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840 → 950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    6. XM_024979623.2 → XP_024835391.1  AP-2 complex subunit beta isoform X1

      UniProtKB/Swiss-Prot
      Q08DS7
      Conserved Domains (4) summary
      smart00809
      Location:731 → 831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840 → 950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63009.2 GenPept UniProtKB/Swiss-Prot:P63009
    Q08DS7.1 GenPept UniProtKB/Swiss-Prot:Q08DS7

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