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    HAPLN3 hyaluronan and proteoglycan link protein 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 515224, updated on 1-Jan-2025

    Summary

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    Official Symbol
    HAPLN3provided by VGNC
    Official Full Name
    hyaluronan and proteoglycan link protein 3provided by VGNC
    Primary source
    VGNC:VGNC:29751
    See related
    BGD:BT29615; Ensembl:ENSBTAG00000001740
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See HAPLN3 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (20449003..20463676, complement)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene myeloid-associated differentiation marker-like Neighboring gene uncharacterized LOC132343337 Neighboring gene aggrecan Neighboring gene uncharacterized LOC132343338 Neighboring gene milk fat globule EGF and factor V/VIII domain containing

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC159574

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in skeletal system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in perineuronal net IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hyaluronan and proteoglycan link protein 3
    NP_001092451.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098981.2 → NP_001092451.1  hyaluronan and proteoglycan link protein 3 precursor

      See identical proteins and their annotated locations for NP_001092451.1

      Status: PROVISIONAL

      Source sequence(s)
      BC142409
      UniProtKB/TrEMBL
      A0AAA9S242, A5PK97, F6QLF1
      Related
      ENSBTAP00000002282.6, ENSBTAT00000002282.6
      Conserved Domains (4) summary
      cd05877
      Location:62 → 167
      Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP)
      smart00410
      Location:63 → 162
      IG_like; Immunoglobulin like
      cd03518
      Location:166 → 260
      Link_domain_HAPLN_module_1; Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding ...
      cd03519
      Location:268 → 357
      Link_domain_HAPLN_module_2; Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      20449003..20463676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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