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    SMAD2 SMAD family member 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 516010, updated on 1-Jan-2025

    Summary

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    Official Symbol
    SMAD2provided by VGNC
    Official Full Name
    SMAD family member 2provided by VGNC
    Primary source
    VGNC:VGNC:34975
    See related
    BGD:BT19091; Ensembl:ENSBTAG00000039916
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SMAD2 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 24 NC_037351.1 (47492798..47583339, complement)

    Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343785 Neighboring gene uncharacterized LOC112444163 Neighboring gene collagen alpha-1(I) chain Neighboring gene zinc finger and BTB domain containing 7C Neighboring gene uncharacterized LOC112444201 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Evidence supporting a role for SMAD2/3 in bovine early embryonic development: potential implications for embryotropic actions of follistatin. Zhang K, et al. Biol Reprod, 2015 Oct. PMID 26289443, Free PMC Article
    2. Physiological and excessive mechanical compression of articular cartilage activates Smad2/3P signaling. Madej W, et al. Osteoarthritis Cartilage, 2014 Jul. PMID 24795273
    3. Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network. Nicklas D, et al. J R Soc Interface, 2013 Sep 6. PMID 23804438, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis
      Title: Evidence supporting a role for SMAD2/3 in bovine early embryonic development: potential implications for embryotropic actions of follistatin.
    2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.
      Title: Physiological and excessive mechanical compression of articular cartilage activates Smad2/3P signaling.
    3. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7.
      Title: Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables I-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in activin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heteromeric SMAD protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mothers against decapentaplegic homolog 2
    Names
    MAD homolog 2
    SMAD 2
    SMAD, mothers against DPP homolog 2
    mothers against DPP homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046218.1 → NP_001039683.1  mothers against decapentaplegic homolog 2

      See identical proteins and their annotated locations for NP_001039683.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ432067
      UniProtKB/Swiss-Prot
      Q1W668
      UniProtKB/TrEMBL
      E1BE92
      Related
      ENSBTAP00000017649.5, ENSBTAT00000017649.6
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037351.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      47492798..47583339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024984267.2 → XP_024840035.1  mothers against decapentaplegic homolog 2 isoform X2

      UniProtKB/TrEMBL
      E1BE92, Q08DE0
      Related
      ENSBTAP00000036451.4, ENSBTAT00000036594.5
      Conserved Domains (2) summary
      cd10491
      Location:8 → 142
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:236 → 426
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    2. XM_024984265.2 → XP_024840033.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      E1BE92
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    3. XM_059880811.1 → XP_059736794.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      E1BE92

    4. XM_024984264.2 → XP_024840032.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      E1BE92
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1W668.1 GenPept UniProtKB/Swiss-Prot:Q1W668

    Gene LinkOut

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