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    SELENOK selenoprotein K [ Bos taurus (domestic cattle) ]

    Gene ID: 615114, updated on 29-Jan-2025

    Summary

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    Gene symbol
    SELENOK
    Gene description
    selenoprotein K
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    SELK
    Summary
    The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. A pseudogene of this locus has been identified on chromosome 5. [provided by RefSeq, Aug 2017]
    Orthologs
    human mouse all
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    Genomic context

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    See SELENOK in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (47024397..47031660)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343469 Neighboring gene elongation factor 1-alpha 1-like Neighboring gene elongation factor 1-alpha 1-like Neighboring gene actin related protein 8 Neighboring gene interleukin 17 receptor B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Forms of selenium in vitamin-mineral mixes differentially affect the expression of genes responsible for prolactin, ACTH, and α-MSH synthesis and mitochondrial dysfunction in pituitaries of steers grazing endophyte-infected tall fescue. Li Q, et al. J Anim Sci, 2019 Feb 1. PMID 30476104, Free PMC Article
    2. Characterization of mammalian selenoproteomes. Kryukov GV, et al. Science, 2003 May 30. PMID 12775843
    3. Selenoprotein Gene Nomenclature. Gladyshev VN, et al. J Biol Chem, 2016 Nov 11. PMID 27645994, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC133565

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in endoplasmic reticulum calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    selenoprotein K

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037489.3 → NP_001032566.2  selenoprotein K

      See identical proteins and their annotated locations for NP_001032566.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the selenoprotein encoding transcript.
      Source sequence(s)
      BC108150, DV802842, EV716815
      UniProtKB/Swiss-Prot
      Q32PE3
      UniProtKB/TrEMBL
      A0A140T8C3
      Related
      ENSBTAP00070045033.1, ENSBTAT00070073929.1
      Conserved Domains (1) summary
      pfam10961
      Location:2 → 92
      SelK_SelG; Selenoprotein SelK_SelG

    RNA

    1. NR_144938.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks an internal exon, and uses an alternate acceptor splice site at another internal exon compared to variant 1. It is represented as non-coding because it lacks a large portion of the coding region, including the translation start codon, found in variant 1.
      Source sequence(s)
      DT858725, EV716815

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      47024397..47031660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32PE3.3 GenPept UniProtKB/Swiss-Prot:Q32PE3

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