SREBF1 sterol regulatory element binding transcription factor 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: SREBF1provided by VGNC
Official Full Name: sterol regulatory element binding transcription factor 1provided by VGNC
Primary source: VGNC:VGNC:35274
See related: BGD:BT10642; Ensembl:ENSBTAG00000007884
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: ADD1; SREBP1; SREBP-1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	19	NC_037346.1 (34633068..34649776)

Chromosome 19 - NC_037346.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of a genetic polymorphism in SREBP1 on fatty acid composition and related gene expression in subcutaneous fat tissue of beef cattle breeds.
Title: Effect of a genetic polymorphism in SREBP1 on fatty acid composition and related gene expression in subcutaneous fat tissue of beef cattle breeds.
We further uncovered that fatty acids are needed for FABP5-mediated SREBP-1c gene expression. Thus, our study demonstrates that FABP5 is a critical regulator of Met- and E2-induced SREBP-1c gene expression leading to milk fat synthesis
Title: FABP5 is a critical regulator of methionine- and estrogen-induced SREBP-1c gene expression in bovine mammary epithelial cells.
U2AF65 functions as a positive regulator of milk synthesis in and proliferation of bovine mammary epithelial cells via the mTOR-SREBP-1c signalling pathway.
Title: U2AF65 enhances milk synthesis and growth of bovine mammary epithelial cells by positively regulating the mTOR-SREBP-1c signalling pathway.
Expression of SCD1 was downregulated through reduced transcription and abundance of the transcription factor sterol regulatory element-binding protein 1 (SREBP1c).This effect was augmented by local chromatin tightening and DNA methylation at and around the SREBP1c binding site in the SCD1 promoter
Title: Epigenetic mechanisms contribute to decrease stearoyl-CoA desaturase 1 expression in the liver of dairy cows after prolonged feeding of high-concentrate diet.
SREBP1a activated while C/EBP factors downregulated the activity of the SCD1 promoter.
Title: Stearoyl-CoA desaturase 1 expression is downregulated in liver and udder during E. coli mastitis through enhanced expression of repressive C/EBP factors and reduced expression of the inducer SREBP1A.
These results suggest that increased expression of hepatic CD36 and SREBP-1 is relevant in the obesity-driven lipid accumulation in the liver of dairy cows during late gestation.
Title: Obesity-driven prepartal hepatic lipid accumulation in dairy cows is associated with increased CD36 and SREBP-1 expression.
Hepatic SREBP-1c-mediated lipid synthesis and the NF-kappaB inflammatory pathway were both overinduced in cows with fatty liver.
Title: SREBP-1c overactivates ROS-mediated hepatic NF-κB inflammatory pathway in dairy cows with fatty liver.
SREBP1 was found to be a key positive regulator of milk fat synthesis and was shown to be regulated by stearic acid and serum.
Title: Function of SREBP1 in the milk fat synthesis of dairy cow mammary epithelial cells.
data suggest that low SREBP-1c expression can decrease lipid synthesis, increase lipid oxidation, and decrease the TG and VLDL content in bovine hepatocytes
Title: SREBP-1c gene silencing can decrease lipid deposits in bovine hepatocytes cultured in vitro.
84-bp indel in intron 5 was significantly associated with palmitoleic acid, stearic acid, saturated fatty acids, triglycerides and the C16 index in Simmental bulls.
Title: Polymorphism of SREBP1 is associated with beef fatty acid composition in Simmental bulls.

Submit: New GeneRIF Correction See all GeneRIFs (21)

General gene information

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Markers

SREBF1 (e-PCR)
- UniSTS:279144

GDB:592734 (e-PCR)
- UniSTS:157917

GDB:592791 (e-PCR)
- UniSTS:157920

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: sterol regulatory element-binding protein 1

Names: adipocyte determination and differentiation-dependent factor 1; sterol response element binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113302.1 → NP_001106773.1 sterol regulatory element-binding protein 1

See identical proteins and their annotated locations for NP_001106773.1

Status: PROVISIONAL

Source sequence(s)

AB355703

UniProtKB/TrEMBL

A0A3Q1MST2, A9CR99

Related

ENSBTAP00000057628.2, ENSBTAT00000072037.2

Conserved Domains (2) summary

cd00083
Location:320 → 377

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam17040
Location:117 → 325

CBP_CCPA; Cellulose-complementing protein A

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

Range

34633068..34649776

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024980343.2 → XP_024836111.1 sterol regulatory element-binding protein 1 isoform X2

UniProtKB/TrEMBL

A0A3Q1MST2

Conserved Domains (2) summary

cd00083
Location:356 → 413

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cl25496
Location:144 → 365

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
XM_059878184.1 → XP_059734167.1 sterol regulatory element-binding protein 1 isoform X1

UniProtKB/TrEMBL

A0A3Q1M285, F6RVY7

Related

ENSBTAP00000010372.5, ENSBTAT00000010372.6