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    CLCA3 chloride channel regulator 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 281694, updated on 30-Jan-2025

    Summary

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    Gene symbol
    CLCA3
    Gene description
    chloride channel regulator 3
    See related
    EnsemblRapid:ENSBTAG00070007514
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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    Genomic context

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    See CLCA3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (57411272..57444878, complement)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL34-like Neighboring gene SH3 domain containing GRB2 like, endophilin B1 Neighboring gene outer dense fiber of sperm tails 2 like Neighboring gene calcium-activated chloride channel Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene chloride channel accessory 4 Neighboring gene chloride channel accessory 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables intracellularly calcium-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    epithelial chloride channel protein
    Names
    calcium-activated chloride channel
    chloride channel, calcium activated, family member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181018.2 → NP_851361.1  epithelial chloride channel protein precursor

      See identical proteins and their annotated locations for NP_851361.1

      Status: PROVISIONAL

      Source sequence(s)
      AF001261
      UniProtKB/TrEMBL
      A0A3Q1MDI0, O18741
      Related
      ENSBTAP00070009874.1, ENSBTAT00070017024.1
      Conserved Domains (3) summary
      cd00198
      Location:308 → 462
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam08434
      Location:24 → 897
      CLCA; Calcium-activated chloride channel
      cl19929
      Location:530 → 570
      A2M_N; MG2 domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      57411272..57444878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005204370.5 → XP_005204427.1  epithelial chloride channel protein isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LUP2
      Conserved Domains (3) summary
      cd00198
      Location:254 → 408
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam08434
      Location:1 → 843
      CLCA; Calcium-activated chloride channel
      cl19929
      Location:476 → 516
      A2M_N; MG2 domain

    2. XM_024984641.2 → XP_024840409.1  epithelial chloride channel protein isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MDI0, F1N4Y8
      Related
      ENSBTAP00070009858.1, ENSBTAT00070017000.1
      Conserved Domains (1) summary
      pfam08434
      Location:32 → 908
      CLCA; Calcium-activated chloride channel
    Nucleotide Protein Strain
    Heading Accession and Version

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