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    TBCD tubulin folding cofactor D [ Bos taurus (domestic cattle) ]

    Gene ID: 281515, updated on 27-Dec-2024

    Summary

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    Official Symbol
    TBCDprovided by VGNC
    Official Full Name
    tubulin folding cofactor Dprovided by VGNC
    Primary source
    VGNC:VGNC:35652
    See related
    BGD:BT17100; Ensembl:ENSBTAG00000015414
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TBCD in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (49768459..49916763, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343104 Neighboring gene meteorin like, glial cell differentiation regulator Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1 Neighboring gene microRNA mir-2344 Neighboring gene zinc finger protein 750 Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene fructosamine 3 kinase Neighboring gene fructosamine 3 kinase related protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Cofactor D functions as a centrosomal protein and is required for the recruitment of the gamma-tubulin ring complex at centrosomes and organization of the mitotic spindle. Cunningham LA, et al. J Biol Chem, 2008 Mar 14. PMID 18171676
    2. Beta-tubulin cofactor D and ARL2 take part in apical junctional complex disassembly and abrogate epithelial structure. Shultz T, et al. FASEB J, 2008 Jan. PMID 17704193
    3. Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity. Tian G, et al. Cytoskeleton (Hoboken), 2010 Nov. PMID 20740604, Free PMC Article
    4. The alpha- and beta-tubulin folding pathways. Lewis SA, et al. Trends Cell Biol, 1997 Dec. PMID 17709011
    5. Pathway leading to correctly folded beta-tubulin. Tian G, et al. Cell, 1996 Jul 26. PMID 8706133

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables beta-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adherens junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in bicellular tight junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in post-chaperonin tubulin folding pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tubulin complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tubulin-specific chaperone D
    Names
    beta-tubulin cofactor D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174194.2 → NP_776619.1  tubulin-specific chaperone D

      Status: PROVISIONAL

      Source sequence(s)
      U61233
      UniProtKB/Swiss-Prot
      Q28205
      UniProtKB/TrEMBL
      A0A3Q1LIQ9
      Related
      ENSBTAP00000059009.2, ENSBTAT00000082949.2
      Conserved Domains (2) summary
      pfam12612
      Location:905 → 1095
      TFCD_C; Tubulin folding cofactor D C terminal
      cl19887
      Location:40 → 597
      TFCD_C; Tubulin folding cofactor D C terminal

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      49768459..49916763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010816446.4 → XP_010814748.1  tubulin-specific chaperone D isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LIQ9
      Conserved Domains (2) summary
      pfam12612
      Location:917 → 1107
      TFCD_C; Tubulin folding cofactor D C terminal
      cl19887
      Location:40 → 609
      TFCD_C; Tubulin folding cofactor D C terminal

    2. XM_010816445.4 → XP_010814747.1  tubulin-specific chaperone D isoform X2

      UniProtKB/TrEMBL
      A0AAA9SWC2, A0AAA9TNW7
      Related
      ENSBTAP00000090769.1, ENSBTAT00000115781.1
      Conserved Domains (2) summary
      pfam12612
      Location:905 → 1095
      TFCD_C; Tubulin folding cofactor D C terminal
      cl19887
      Location:40 → 597
      TFCD_C; Tubulin folding cofactor D C terminal

    3. XM_010816444.4 → XP_010814746.1  tubulin-specific chaperone D isoform X1

      UniProtKB/TrEMBL
      A0AAA9TNW7
      Conserved Domains (3) summary
      pfam12612
      Location:917 → 1107
      TFCD_C; Tubulin folding cofactor D C terminal
      sd00044
      Location:380 → 408
      HEAT; HEAT repeat [structural motif]
      cl19887
      Location:40 → 609
      TFCD_C; Tubulin folding cofactor D C terminal

    4. XM_024979598.2 → XP_024835366.1  tubulin-specific chaperone D isoform X4

      UniProtKB/TrEMBL
      A0AAA9TNW7
      Conserved Domains (2) summary
      pfam12612
      Location:837 → 1024
      TFCD_C; Tubulin folding cofactor D C terminal
      cl19887
      Location:3 → 526
      TFCD_C; Tubulin folding cofactor D C terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28205.1 GenPept UniProtKB/Swiss-Prot:Q28205

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials