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    ADORA1 adenosine A1 receptor [ Bos taurus (domestic cattle) ]

    Gene ID: 282133, updated on 1-Jan-2025

    Summary

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    Official Symbol
    ADORA1provided by VGNC
    Official Full Name
    adenosine A1 receptorprovided by VGNC
    Primary source
    VGNC:VGNC:25686
    See related
    BGD:BT18639; Ensembl:ENSBTAG00000011461
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ADORA1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (915626..956850)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene annexin A2-like Neighboring gene myosin binding protein H Neighboring gene chitinase 3 like 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling. Umapathy SN, et al. PLoS One, 2013. PMID 23613714, Free PMC Article
    2. Homodimerization of adenosine A₁ receptors in brain cortex explains the biphasic effects of caffeine. Gracia E, et al. Neuropharmacology, 2013 Aug. PMID 23523559
    3. Cloning, expression, and characterization of the unique bovine A1 adenosine receptor. Studies on the ligand binding site by site-directed mutagenesis. Olah ME, et al. J Biol Chem, 1992 May 25. PMID 1587851, Free PMC Article
    4. Cloning and expression of a bovine adenosine A1 receptor cDNA. Tucker AL, et al. FEBS Lett, 1992 Feb 3. PMID 1551415
    5. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that that ADORA1 forms homomers/homodimers in brain cortex.
      Title: Homodimerization of adenosine A₁ receptors in brain cortex explains the biphasic effects of caffeine.
    2. Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling.
      Title: Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled adenosine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled adenosine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenosine receptor A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174497.3 → NP_776922.2  adenosine receptor A1

      See identical proteins and their annotated locations for NP_776922.2

      Status: PROVISIONAL

      Source sequence(s)
      BT021759
      UniProtKB/Swiss-Prot
      A5PJR1, P28190, Q58D38
      Conserved Domains (2) summary
      cd14964
      Location:12 → 36
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:10 → 299
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      915626..956850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005216653.5 → XP_005216710.1  adenosine receptor A1 isoform X1

      See identical proteins and their annotated locations for XP_005216710.1

      UniProtKB/Swiss-Prot
      A5PJR1, P28190, Q58D38
      Related
      ENSBTAP00000071730.1, ENSBTAT00000072690.2
      Conserved Domains (2) summary
      cd14964
      Location:12 → 36
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:10 → 299
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28190.3 GenPept UniProtKB/Swiss-Prot:P28190

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.