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    GUCY2C guanylate cyclase 2C [ Bos taurus (domestic cattle) ]

    Gene ID: 282244, updated on 29-Jan-2025

    Summary

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    Official Symbol
    GUCY2Cprovided by VGNC
    Official Full Name
    guanylate cyclase 2Cprovided by VGNC
    Primary source
    VGNC:VGNC:29722
    See related
    BGD:BT10631; Ensembl:ENSBTAG00000019722
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See GUCY2C in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (95137271..95238347)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene chromosome 5 C12orf60 homolog Neighboring gene ADP-ribosyltransferase 4 Neighboring gene single-pass membrane protein with coiled-coil domains 3 Neighboring gene WW domain binding protein 11 Neighboring gene H4 histone 16 Neighboring gene H2A.J histone Neighboring gene hyaluronan synthase 2-like Neighboring gene phospholipase B domain containing 1 Neighboring gene dnaJ homolog subfamily A member 1-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor guanylyl cyclase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanylyl cyclase C
    Names
    guanylate cyclase 2C (heat stable enterotoxin receptor)
    heat-stable enterotoxin receptor
    NP_776972.1
    XP_059742097.1
    XP_059742098.1
    XP_059742099.1
    XP_059742100.1
    XP_059742101.1
    XP_059742102.1
    XP_059742103.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174547.2 → NP_776972.1  guanylyl cyclase C precursor

      See identical proteins and their annotated locations for NP_776972.1

      Status: PROVISIONAL

      Source sequence(s)
      AF081464
      UniProtKB/TrEMBL
      A0AAA9RW39, O77690
      Related
      ENSBTAP00070040180.1, ENSBTAT00070066114.1
      Conserved Domains (5) summary
      cd06369
      Location:35 → 414
      PBP1_GC_C_enterotoxin_receptor; Ligand-binding domain of the membrane guanylyl cyclase C
      smart00044
      Location:787 → 978
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:479 → 749
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      pfam00211
      Location:814 → 1001
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07714
      Location:501 → 744
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      95137271..95238347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059886118.1 → XP_059742101.1  guanylyl cyclase C isoform X3

      UniProtKB/TrEMBL
      A0AAA9SZD1

    2. XM_059886120.1 → XP_059742103.1  guanylyl cyclase C isoform X4

      UniProtKB/TrEMBL
      A0AAA9SZD1

    3. XM_059886116.1 → XP_059742099.1  guanylyl cyclase C isoform X3

      UniProtKB/TrEMBL
      A0AAA9SZD1

    4. XM_059886117.1 → XP_059742100.1  guanylyl cyclase C isoform X3

      UniProtKB/TrEMBL
      A0AAA9SZD1

    5. XM_059886119.1 → XP_059742102.1  guanylyl cyclase C isoform X3

      UniProtKB/TrEMBL
      A0AAA9SZD1
      Related
      ENSBTAP00070040098.1, ENSBTAT00070066026.1

    6. XM_059886115.1 → XP_059742098.1  guanylyl cyclase C isoform X2

      UniProtKB/TrEMBL
      A0AAA9RW39

    7. XM_059886114.1 → XP_059742097.1  guanylyl cyclase C isoform X1

      UniProtKB/TrEMBL
      A0AAA9RW39, F1N5B2
      Related
      ENSBTAP00070040149.1, ENSBTAT00070066081.1
    Nucleotide Protein Strain
    Heading Accession and Version

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