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    ACACA acetyl-CoA carboxylase alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 281590, updated on 1-Jan-2025

    Summary

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    Official Symbol
    ACACAprovided by VGNC
    Official Full Name
    acetyl-CoA carboxylase alphaprovided by VGNC
    Primary source
    VGNC:VGNC:25519
    See related
    BGD:BT12301; Ensembl:ENSBTAG00000017567
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ACC1; ACCA
    Orthologs
    human mouse all
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    Genomic context

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    See ACACA in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    62
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (13439554..13726306, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene LIM homeobox 1 Neighboring gene apoptosis antagonizing transcription factor Neighboring gene U6atac minor spliceosomal RNA Neighboring gene uncharacterized LOC112442606 Neighboring gene chromosome 19 C17orf78 homolog Neighboring gene uncharacterized LOC132343012 Neighboring gene transcriptional adaptor 2A Neighboring gene dual specificity phosphatase 14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Characterization of a far upstream located promoter expressing the acetyl-CoA carboxylase-alpha in the brain of cattle. Shi X, et al. Gene, 2013 Feb 25. PMID 23262334
    2. The SNPs in the ACACA gene are effective on fatty acid composition in Holstein milk. Matsumoto H, et al. Mol Biol Rep, 2012 Sep. PMID 22718502
    3. Genomic distribution of three promoters of the bovine gene encoding acetyl-CoA carboxylase alpha and evidence that the nutritionally regulated promoter I contains a repressive element different from that in rat. Mao J, et al. Biochem J, 2001 Aug 15. PMID 11485560, Free PMC Article
    4. Associations of polymorphisms in the promoter I of bovine acetyl-CoA carboxylase-alpha gene with beef fatty acid composition. Zhang S, et al. Anim Genet, 2010 Aug. PMID 20002363
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression profiles showed that PI is the promoter driving expression of the dominant ACACA-transcript in brain.
      Title: Characterization of a far upstream located promoter expressing the acetyl-CoA carboxylase-alpha in the brain of cattle.
    2. Since the promoter region, PIII, is specific to mammary gland during lactation, the altered expression of the ACACA gene owing to the SNPs in the PIII region may influence the fatty acid composition in the milk.
      Title: The SNPs in the ACACA gene are effective on fatty acid composition in Holstein milk.
    3. results suggested that the SNPs in the promoter I region of ACACA gene are associated with variations in the fatty acid contents in longissimus dorsi muscle.
      Title: Associations of polymorphisms in the promoter I of bovine acetyl-CoA carboxylase-alpha gene with beef fatty acid composition.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables acetyl-CoA carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acetyl-CoA carboxylase 1
    Names
    ACC-alpha
    acetyl-coenzyme A carboxylase alpha
    NP_776649.1
    XP_005220032.1
    XP_005220033.1
    XP_005220034.1
    XP_005220035.1
    XP_010814045.1
    XP_024835369.1
    XP_024835371.1
    XP_024835374.1
    XP_024835375.1
    XP_059733697.1
    XP_059733698.1
    XP_059733699.1
    XP_059733700.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174224.2 → NP_776649.1  acetyl-CoA carboxylase 1

      See identical proteins and their annotated locations for NP_776649.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ132890
      UniProtKB/Swiss-Prot
      Q9TTS3
      UniProtKB/TrEMBL
      A0A3Q1MAY0
      Related
      ENSBTAP00000023364.5, ENSBTAT00000023364.7
      Conserved Domains (5) summary
      COG0439
      Location:118 → 620
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:671 → 818
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:754 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1669 → 2217
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:820 → 1569
      ACC_central; Acetyl-CoA carboxylase, central region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      13439554..13726306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024979601.2 → XP_024835369.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LIN4
      Conserved Domains (5) summary
      COG0439
      Location:155 → 657
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:790 → 855
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1698 → 2246
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:857 → 1591
      ACC_central; Acetyl-CoA carboxylase, central region
      cl27427
      Location:708 → 855
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

    2. XM_005219975.5 → XP_005220032.1  acetyl-CoA carboxylase 1 isoform X1

      See identical proteins and their annotated locations for XP_005220032.1

      UniProtKB/TrEMBL
      A0A3Q1LIN4, A0A3Q1MUW1
      Related
      ENSBTAP00000074493.1, ENSBTAT00000087370.2
      Conserved Domains (8) summary
      COG0439
      Location:155 → 657
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:708 → 855
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:155 → 274
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:790 → 855
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1706 → 2254
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:544 → 651
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:857 → 1606
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:316 → 507
      ATP-grasp_4; ATP-grasp domain

    3. XM_059877716.1 → XP_059733699.1  acetyl-CoA carboxylase 1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MAY0, E1BGH6

    4. XM_059877715.1 → XP_059733698.1  acetyl-CoA carboxylase 1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MAY0, E1BGH6

    5. XM_010815743.4 → XP_010814045.1  acetyl-CoA carboxylase 1 isoform X4

      See identical proteins and their annotated locations for XP_010814045.1

      UniProtKB/TrEMBL
      A0A3Q1MAY0, E1BGH6
      Related
      ENSBTAP00000067794.2, ENSBTAT00000080617.2
      Conserved Domains (5) summary
      COG0439
      Location:118 → 620
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:753 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1669 → 2217
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:820 → 1562
      ACC_central; Acetyl-CoA carboxylase, central region
      cl27427
      Location:671 → 818
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

    6. XM_005219976.5 → XP_005220033.1  acetyl-CoA carboxylase 1 isoform X4

      See identical proteins and their annotated locations for XP_005220033.1

      UniProtKB/TrEMBL
      A0A3Q1MAY0, E1BGH6
      Conserved Domains (5) summary
      COG0439
      Location:118 → 620
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:753 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1669 → 2217
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:820 → 1562
      ACC_central; Acetyl-CoA carboxylase, central region
      cl27427
      Location:671 → 818
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

    7. XM_024979603.2 → XP_024835371.1  acetyl-CoA carboxylase 1 isoform X5

      UniProtKB/TrEMBL
      F1MSC3
      Related
      ENSBTAP00000029559.6, ENSBTAT00000029560.6
      Conserved Domains (5) summary
      COG0439
      Location:118 → 620
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:753 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1661 → 2209
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:820 → 1554
      ACC_central; Acetyl-CoA carboxylase, central region
      cl27427
      Location:671 → 818
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

    8. XM_005219978.5 → XP_005220035.1  acetyl-CoA carboxylase 1 isoform X4

      See identical proteins and their annotated locations for XP_005220035.1

      UniProtKB/TrEMBL
      A0A3Q1MAY0, E1BGH6
      Conserved Domains (5) summary
      COG0439
      Location:118 → 620
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:753 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1669 → 2217
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:820 → 1562
      ACC_central; Acetyl-CoA carboxylase, central region
      cl27427
      Location:671 → 818
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

    9. XM_059877714.1 → XP_059733697.1  acetyl-CoA carboxylase 1 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LIN4
      Related
      ENSBTAP00000058963.2, ENSBTAT00000085804.2

    10. XM_059877717.1 → XP_059733700.1  acetyl-CoA carboxylase 1 isoform X7

      UniProtKB/TrEMBL
      F1MSC3

    11. XM_024979606.2 → XP_024835374.1  acetyl-CoA carboxylase 1 isoform X8

      UniProtKB/TrEMBL
      F1MSC3
      Conserved Domains (5) summary
      COG0439
      Location:60 → 562
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:695 → 760
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1603 → 2151
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:762 → 1496
      ACC_central; Acetyl-CoA carboxylase, central region
      cl27427
      Location:613 → 760
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

    12. XM_005219977.5 → XP_005220034.1  acetyl-CoA carboxylase 1 isoform X6

      See identical proteins and their annotated locations for XP_005220034.1

      UniProtKB/TrEMBL
      A0A3Q1M483, A0A3Q1MAY0
      Related
      ENSBTAP00000065001.1, ENSBTAT00000075315.2
      Conserved Domains (8) summary
      COG0439
      Location:60 → 562
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:613 → 760
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:60 → 179
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:695 → 760
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1611 → 2159
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:449 → 556
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:762 → 1511
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:221 → 412
      ATP-grasp_4; ATP-grasp domain

    13. XM_024979607.2 → XP_024835375.1  acetyl-CoA carboxylase 1 isoform X9

      UniProtKB/TrEMBL
      F1MSC3
      Conserved Domains (5) summary
      COG0439
      Location:18 → 473
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:606 → 671
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1522 → 2070
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:673 → 1415
      ACC_central; Acetyl-CoA carboxylase, central region
      cl27427
      Location:524 → 671
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TTS3.1 GenPept UniProtKB/Swiss-Prot:Q9TTS3

    Gene LinkOut

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