SOD2 superoxide dismutase 2 [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: SOD2
Gene description: superoxide dismutase 2
See related: BGD:BT29128; Ensembl:ENSBTAG00000006523
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: MnSOD; SOD2X1; SOD2X2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	9	NC_037336.1 (95955349..95965385, complement)

Chromosome 9 - NC_037336.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected.
Title: Altered expression of inflammation-associated genes in oviductal cells following follicular fluid exposure: implications for ovarian carcinogenesis.
Data suggest that during ectogenesis of blastocysts infected with bovine Herpesvirus type 5, expression of SOD2 (Mn) remains high indicating intense mitochondrial activity; this effect may be involved in inhibition of apoptosis in infected embryos.
Title: Evaluation of developmental changes in bovine in vitro produced embryos following exposure to bovine Herpesvirus type 5.
expression profile of SOD2 in follicles: oocytes (SOD2 restricted to ooplasm); cumulus cells (expressed some SOD2); follicular fluid (small follicles show increased amounts of SOD2 in comparison with large follicles)
Title: Profiling of superoxide dismutase isoenzymes in compartments of the developing bovine antral follicles.
Heart mitochondrial nucleoids contained SOD2, aortic endothelial cell mitochondrial nucleoids did not
Title: Association of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituents.
The expression of SOD1 and SOD2 through the course of the estrous cycle is reported.
Title: Expression of superoxide dismutases in the bovine oviduct during the estrous cycle.
Shear stress influences spatial variations in vascular Mn-SOD expression with implications for LDL nitration.
Title: Shear stress influences spatial variations in vascular Mn-SOD expression: implication for LDL nitration.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables superoxide dismutase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in superoxide metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: superoxide dismutase [Mn], mitochondrial

Names: manganous superoxide dismutase; superoxide dismutase 2, mitochondrial

NP_963285.2

EC 1.15.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201527.2 → NP_963285.2 superoxide dismutase [Mn], mitochondrial precursor

See identical proteins and their annotated locations for NP_963285.2

Status: PROVISIONAL

Source sequence(s)

BC105378

UniProtKB/Swiss-Prot

P41976, Q2KJE8, Q5E9D2, Q862F8

UniProtKB/TrEMBL

A0AAA9U061

Related

ENSBTAP00070046989.1, ENSBTAT00070077133.1

Conserved Domains (3) summary

COG0605
Location:23 → 219

SodA; Superoxide dismutase [Inorganic ion transport and metabolism]

pfam00081
Location:25 → 106

Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain

pfam02777
Location:113 → 216

Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain