U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CD8A CD8 subunit alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 281060, updated on 1-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    CD8Aprovided by VGNC
    Official Full Name
    CD8 subunit alphaprovided by VGNC
    Primary source
    VGNC:VGNC:27052
    See related
    BGD:BT12138; Ensembl:ENSBTAG00000021141
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CD8A in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (48118106..48125250)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene TBP protein-like pseudogene Neighboring gene CD8 subunit beta Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene ring finger protein 103

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular cloning, reconstruction and expression of the gene encoding the alpha-chain of the bovine CD8--definition of three peptide regions conserved across species. Lalor P, et al. Immunology, 1992 May. PMID 1628904, Free PMC Article
    2. Calyculin A inhibits expression of CD8alpha but not CD4 in human peripheral blood T cells. Allam A, et al. Immunobiology, 2000 Nov. PMID 11131152
    3. Zinc is essential for binding of p56(lck) to CD4 and CD8alpha. Lin RS, et al. J Biol Chem, 1998 Dec 4. PMID 9830036
    4. Molecular biology and function of CD4 and CD8. Parnes JR. Adv Immunol, 1989. PMID 2493728
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in T cell mediated immunity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytotoxic T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    T-cell surface glycoprotein CD8 alpha chain
    Names
    CD8 antigen, alpha polypeptide (p32)
    CD8a molecule

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174015.2 → NP_776440.2  T-cell surface glycoprotein CD8 alpha chain precursor

      Status: VALIDATED

      Source sequence(s)
      NKLS02000011
      Related
      ENSBTAP00000028175.3, ENSBTAT00000028175.4

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      48118106..48125250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31783.1 GenPept UniProtKB/Swiss-Prot:P31783

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials