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    PPIA peptidylprolyl isomerase A [ Bos taurus (domestic cattle) ]

    Gene ID: 281418, updated on 1-Jan-2025

    Summary

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    Gene symbol
    PPIA
    Gene description
    peptidylprolyl isomerase A
    See related
    Ensembl:ENSBTAG00000012003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PPIA in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (76709294..76713267, complement)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene microRNA mir-4657 Neighboring gene H2A.Z variant histone 2 Neighboring gene zinc finger MIZ-type containing 2 Neighboring gene oxoglutarate dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Isolation and amino acid sequence of cyclophilin. Harding MW, et al. J Biol Chem, 1986 Jun 25. PMID 3522572
    2. Direct effects of nerve growth factor on thecal cells from antral ovarian follicles. Dissen GA, et al. Endocrinology, 2000 Dec. PMID 11108289
    3. Pituitary genomic expression profiles of steers are altered by grazing of high vs. low endophyte-infected tall fescue forages. Li Q, et al. PLoS One, 2017. PMID 28902910, Free PMC Article
    4. The small GTPase RAB28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium. Ying G, et al. J Biol Chem, 2018 Nov 9. PMID 30228185, Free PMC Article
    5. Characterization of gene expression profiles in early bovine pregnancy using a custom cDNA microarray. Ishiwata H, et al. Mol Reprod Dev, 2003 May. PMID 12658628

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase A
    Names
    PPIase A
    cyclophilin A
    cyclophilin T
    cyclophilin T-cell
    cyclosporin A-binding protein
    peptidylprolyl isomerase A (cyclophilin A)
    rotamase A
    NP_847890.2
    XP_010802660.1
    XP_059741378.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178320.3 → NP_847890.2  peptidyl-prolyl cis-trans isomerase A

      Status: VALIDATED

      Source sequence(s)
      NKLS02000004
      UniProtKB/TrEMBL
      G3X8B1
      Related
      ENSBTAP00000015924.4, ENSBTAT00000015924.5

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      76709294..76713267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010804358.4 → XP_010802660.1  peptidyl-prolyl cis-trans isomerase A isoform X2

      UniProtKB/TrEMBL
      A0A3Q1M9Y7
      Conserved Domains (1) summary
      cl00197
      Location:1 → 102
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    2. XM_059885395.1 → XP_059741378.1  peptidyl-prolyl cis-trans isomerase A isoform X2

      UniProtKB/TrEMBL
      A0A3Q1M9Y7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62935.2 GenPept UniProtKB/Swiss-Prot:P62935

    Gene LinkOut

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