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    FGF1 fibroblast growth factor 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281160, updated on 1-Jan-2025

    Summary

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    Official Symbol
    FGF1provided by VGNC
    Official Full Name
    fibroblast growth factor 1provided by VGNC
    Primary source
    VGNC:VGNC:28970
    See related
    BGD:BT11042; Ensembl:ENSBTAG00000005198
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ECGF; EDGF; aFGF; FGF-1; FGF2B; HBGF-1; EDGF II
    Orthologs
    human mouse all
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    Genomic context

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    See FGF1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (53622268..53729306, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112447553 Neighboring gene uncharacterized LOC100847454 Neighboring gene sprouty RTK signaling antagonist 4 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene microRNA mir-2460 Neighboring gene Rho GTPase activating protein 26 Neighboring gene uncharacterized LOC132345824 Neighboring gene uncharacterized LOC107132646 Neighboring gene nuclear receptor subfamily 3 group C member 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Complete primary structure of prostatropin, a prostate epithelial cell growth factor. Crabb JW, et al. Biochemistry, 1986 Sep 9. PMID 3768327
    2. Cloning of two different 5' untranslated exons of bovine acidic fibroblast growth factor by the single strand ligation to single-stranded cDNA methodology. Philippe JM, et al. Biochem Biophys Res Commun, 1992 Oct 30. PMID 1280126
    3. Characterization of a bovine acidic FGF cDNA clone and its expression in brain and retina. Alterio J, et al. FEBS Lett, 1988 Dec 19. PMID 2849564
    4. Nucleotide sequence of bovine acidic fibroblast growth factor cDNA. Halley C, et al. Nucleic Acids Res, 1988 Nov 25. PMID 3205724, Free PMC Article
    5. Structural evidence that endothelial cell growth factor beta is the precursor of both endothelial cell growth factor alpha and acidic fibroblast growth factor. Burgess WH, et al. Proc Natl Acad Sci U S A, 1986 Oct. PMID 3532107, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FGF1 and FGF7 may be involved differently in the process of follicle maturation and CL formation, which is strongly dependent on angiogenesis
      Title: Expression of fibroblast growth factor 1 (FGF1) and FGF7 in mature follicles during the periovulatory period after GnRH in the cow.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lung development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in wound healing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibroblast growth factor 1
    Names
    acidic eye-derived growth factor II
    acidic fibroblast growth factor
    endothelial cell growth factor beta and alpha chains
    endothelial growth factor
    fibroblast growth factor 1 (acidic)
    fibroblast growth factor 2B
    fibroblast growth factor, acidic
    heparin-binding growth factor 1
    prostatropin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001314006.1 → NP_001300935.1  fibroblast growth factor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      BC103225, DV846120, EH374181, NKLS02000007
      UniProtKB/Swiss-Prot
      P03968, Q3ZBL8
      UniProtKB/TrEMBL
      A0A7U3JWD0
      Related
      ENSBTAP00000058186.1, ENSBTAT00000072959.1
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    2. NM_174055.3 → NP_776480.1  fibroblast growth factor 1

      See identical proteins and their annotated locations for NP_776480.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      EH374181, NKLS02000007
      UniProtKB/Swiss-Prot
      P03968, Q3ZBL8
      UniProtKB/TrEMBL
      A0A7U3JWD0
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      53622268..53729306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015472279.3 → XP_015327765.1  fibroblast growth factor 1 isoform X2

      Conserved Domains (1) summary
      pfam00167
      Location:25 → 147
      FGF; Fibroblast growth factor

    2. XM_015472275.3 → XP_015327761.1  fibroblast growth factor 1 isoform X1

      UniProtKB/Swiss-Prot
      P03968, Q3ZBL8
      UniProtKB/TrEMBL
      A0A7U3JWD0
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    3. XM_015472276.3 → XP_015327762.1  fibroblast growth factor 1 isoform X1

      UniProtKB/Swiss-Prot
      P03968, Q3ZBL8
      UniProtKB/TrEMBL
      A0A7U3JWD0
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    4. XM_059887924.1 → XP_059743907.1  fibroblast growth factor 1 isoform X1

      UniProtKB/Swiss-Prot
      P03968, Q3ZBL8
      UniProtKB/TrEMBL
      A0A7U3JWD0

    5. XM_024993833.2 → XP_024849601.1  fibroblast growth factor 1 isoform X1

      UniProtKB/Swiss-Prot
      P03968, Q3ZBL8
      UniProtKB/TrEMBL
      A0A7U3JWD0
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    6. XM_024993834.2 → XP_024849602.1  fibroblast growth factor 1 isoform X1

      UniProtKB/Swiss-Prot
      P03968, Q3ZBL8
      UniProtKB/TrEMBL
      A0A7U3JWD0
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    7. XM_015472277.3 → XP_015327763.1  fibroblast growth factor 1 isoform X1

      UniProtKB/Swiss-Prot
      P03968, Q3ZBL8
      UniProtKB/TrEMBL
      A0A7U3JWD0
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    8. XM_015472280.3 → XP_015327766.1  fibroblast growth factor 1 isoform X3

      UniProtKB/TrEMBL
      A0AAF7AQL1
      Related
      ENSBTAP00000073018.2, ENSBTAT00000068787.2
      Conserved Domains (1) summary
      cl00060
      Location:25 → 57
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P03968.2 GenPept UniProtKB/Swiss-Prot:P03968

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