ELN elastin [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: ELN
Gene description: elastin
See related: BGD:BT12393; Ensembl:ENSBTAG00000019517
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	25	NC_037352.1 (33277411..33310464, complement)

Chromosome 25 - NC_037352.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we show on the molecular level that elastin formation involves random cross-linking of tropoelastin monomers resulting in an unordered network, an unexpected finding compared with previous assumptions of an overall beaded structure
Title: Elastin is heterogeneously cross-linked.
Data suggest that cross-linking involving desmosine and isodesmosine residues in bovine elastin and human tropoelastin contributes to long-term stability of these proteins.
Title: Fingerprinting desmosine-containing elastin peptides.
Immersing elastin in various glycerol-water mixtures, we observe at room temperature that the protein mobility is higher for lower glycerol fractions in the solvent and, thus, lower solvent viscosity.
Title: Effects of solvent concentration and composition on protein dynamics: 13C MAS NMR studies of elastin in glycerol-water mixtures.
domain 36 of tropoelastin contributes to the binding to fibrillin-1 and microfibril-associated glycoprotein through two cysteine residues and Lysine-Arginine-Lysine-Arginine sequence, resulting in the promotion of elastic fiber assembly.
Title: Domain 36 of tropoelastin in elastic fiber formation.
Biaxial force-controlled experiments were used to quantify regional variations in the anisotropy and nonlinearity of elastin isolated from bovine aortic tissues proximal and distal to the heart.
Title: Regional variations in the nonlinearity and anisotropy of bovine aortic elastin.
the mechanism by which ONOO(-) prevents cell binding to TE is by introducing negatively charged sulfonic acid residues near the positively charged cluster.
Title: Oxidative modifications of the C-terminal domain of tropoelastin prevent cell binding.
analysis of functional inactivation of the tropoelastin carboxy-terminal domain in cross-linked elastin
Title: Modification and functional inactivation of the tropoelastin carboxy-terminal domain in cross-linked elastin.
self-association and oxidation by lysyl oxidase precedes tropoelastin deposition onto microfibrils; the entire molecule of tropoelastin is required for this following maturation process
Title: Distinct steps of cross-linking, self-association, and maturation of tropoelastin are necessary for elastic fiber formation.
In cases of vascular calcification, the decreased expression of tropoelastin may be partially responsible for decreased vascular elasticity and also for the decreased formation of new elastic fibers.
Title: Accelerated calcification represses the expression of elastic fiber components and lysyl oxidase in cultured bovine aortic smooth muscle cells.
tropoelastin has domains that mediate elastin deposition in vitro and in vivo
Title: Domains in tropoelastin that mediate elastin deposition in vitro and in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

ELN (e-PCR), detects polymorphism
- UniSTS:251398

GDB:3754258 (e-PCR)
- UniSTS:25142

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: elastin

Names: elastin (supravalvular aortic stenosis, Williams-Beuren syndrome); tropoelastin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.