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    TGM2 transglutaminase 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281528, updated on 30-Jan-2025

    Summary

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    Official Symbol
    TGM2provided by VGNC
    Official Full Name
    transglutaminase 2provided by VGNC
    Primary source
    VGNC:VGNC:35810
    See related
    BGD:BT15293; EnsemblRapid:ENSBTAG00070036035
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    TG
    Orthologs
    human mouse all
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    Genomic context

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    See TGM2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (67002550..67037025, complement)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene TELO2 interacting protein 1 Neighboring gene regulation of nuclear pre-mRNA domain containing 1B Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC104973875 Neighboring gene KIAA1755

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation. Penumatsa KC, et al. Am J Physiol Lung Cell Mol Physiol, 2014 Oct 1. PMID 25128524, Free PMC Article
    2. Cross-linking of osteopontin by tissue transglutaminase increases its collagen binding properties. Kaartinen MT, et al. J Biol Chem, 1999 Jan 15. PMID 9880554
    3. Retinol-induced morphological changes of cultured bovine endothelial cells are accompanied by a marked increase in transglutaminase. Nara K, et al. J Biol Chem, 1989 Nov 15. PMID 2572599
    4. Cloning and sequence analysis of cDNA clones for bovine aortic-endothelial-cell transglutaminase. Nakanishi K, et al. Eur J Biochem, 1991 Nov 15. PMID 1682150
    5. External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification. Johnson KA, et al. J Biol Chem, 2005 Apr 15. PMID 15691824

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TG2 contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.
      Title: Tissue transglutaminase promotes serotonin-induced AKT signaling and mitogenesis in pulmonary vascular smooth muscle cells.
    2. An important role for TG2, mediated by intracellular calcium fluxes and HIF1A, in hypoxia-induced pulmonary artery smooth muscle cells proliferation.
      Title: Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation.
    3. externalized GTP-bound TG2 serves as a molecular switch for differentiation of chondrocytes to a hypertrophic, calcifying phenotype in a manner that does not require either TG2 transamidation activity or fibronectin binding
      Title: External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein-glutamine gamma-glutamyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide cross-linking IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein-glutamine gamma-glutamyltransferase 2
    Names
    TG(C)
    TGC
    TGase C
    TGase-2
    isopeptidase TGM2
    protein-glutamine deamidase TGM2
    protein-glutamine dopaminyltransferase TGM2
    protein-glutamine histaminyltransferase TGM2
    protein-glutamine noradrenalinyltransferase TGM2
    protein-glutamine serotonyltransferase TGM2
    tissue transglutaminase
    transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
    transglutaminase C
    NP_803473.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177507.2 → NP_803473.1  protein-glutamine gamma-glutamyltransferase 2

      See identical proteins and their annotated locations for NP_803473.1

      Status: PROVISIONAL

      Source sequence(s)
      X60686
      UniProtKB/Swiss-Prot
      P51176, Q3ZBH7
      UniProtKB/TrEMBL
      A0A140T892
      Related
      ENSBTAP00070048939.1, ENSBTAT00070080786.1
      Conserved Domains (4) summary
      smart00460
      Location:269 → 361
      TGc; Transglutaminase/protease-like homologues
      COG1305
      Location:271 → 369
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam00868
      Location:6 → 120
      Transglut_N; Transglutaminase family
      pfam00927
      Location:587 → 686
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      67002550..67037025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51176.1 GenPept UniProtKB/Swiss-Prot:P51176

    Gene LinkOut

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