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    NDUFS8 NADH:ubiquinone oxidoreductase core subunit S8 [ Bos taurus (domestic cattle) ]

    Gene ID: 287027, updated on 29-Jan-2025

    Summary

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    Official Symbol
    NDUFS8provided by VGNC
    Official Full Name
    NADH:ubiquinone oxidoreductase core subunit S8provided by VGNC
    Primary source
    VGNC:VGNC:31973
    See related
    BGD:BT21452; Ensembl:ENSBTAG00000012072
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NDUFS8 in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (45559234..45563284)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene unc-93 homolog B1, TLR signaling regulator Neighboring gene aldehyde dehydrogenase 3 family member B1 Neighboring gene uncharacterized LOC112444853 Neighboring gene T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 Neighboring gene choline kinase alpha Neighboring gene serine/arginine repetitive matrix protein 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A homologue of a nuclear-coded iron-sulfur protein subunit of bovine mitochondrial complex I is encoded in chloroplast genomes. Dupuis A, et al. Biochemistry, 1991 Mar 19. PMID 1901022
    2. Architecture of mammalian respiratory complex I. Vinothkumar KR, et al. Nature, 2014 Nov 6. PMID 25209663, Free PMC Article
    3. Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry. Murray J, et al. J Biol Chem, 2003 Sep 26. PMID 12857734
    4. Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme. Sazanov LA, et al. Biochemistry, 2000 Jun 20. PMID 10852722
    5. Subunit analysis of bovine heart complex I by reversed-phase high-performance liquid chromatography, electrospray ionization-tandem mass spectrometry, and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry. Lemma-Gray P, et al. Anal Biochem, 2008 Nov 15. PMID 18721790, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC134156

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables NADH dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
    Names
    CI-23kD
    NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
    NADH dehydrogenase ubiquinone Fe-S 8
    NADH-ubiquinone oxidoreductase 23 kDa subunit
    TYKY subunit
    complex I-23kD
    NP_001289598.1
    XP_005227039.2
    XP_005227041.1
    XP_015316736.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302669.1 → NP_001289598.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

      See identical proteins and their annotated locations for NP_001289598.1

      Status: VALIDATED

      Source sequence(s)
      DT719975, DV906691
      UniProtKB/Swiss-Prot
      P42028, Q32KV7
      UniProtKB/TrEMBL
      A0AAF6ZWB7
      Conserved Domains (1) summary
      PRK05888
      Location:56 → 212
      PRK05888; NADH dehydrogenase subunit I; Provisional

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      45559234..45563284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005226984.3 → XP_005227041.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X3

      See identical proteins and their annotated locations for XP_005227041.1

      UniProtKB/Swiss-Prot
      P42028, Q32KV7
      UniProtKB/TrEMBL
      A0AAF6ZWB7
      Related
      ENSBTAP00070043870.1, ENSBTAT00070071850.1
      Conserved Domains (1) summary
      PRK05888
      Location:56 → 212
      PRK05888; NADH dehydrogenase subunit I; Provisional

    2. XM_005226982.4 → XP_005227039.2  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0AAA9S8H5, A0AAF6ZWB7
      Conserved Domains (1) summary
      PRK05888
      Location:77 → 233
      PRK05888; NADH dehydrogenase subunit I; Provisional

    3. XM_015461250.2 → XP_015316736.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0AAF6ZWB7
      Conserved Domains (2) summary
      PRK05888
      Location:61 → 217
      PRK05888; NADH dehydrogenase subunit I; Provisional
      pfam13484
      Location:117 → 168
      Fer4_16; 4Fe-4S double cluster binding domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_174818.3: Suppressed sequence

      Description
      NM_174818.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42028.1 GenPept UniProtKB/Swiss-Prot:P42028

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.