CD44 CD44 molecule [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CD44provided by VGNC
Official Full Name: CD44 moleculeprovided by VGNC
Primary source: VGNC:VGNC:54629
See related: Ensembl:ENSBTAG00000011578
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	15	NC_037342.1 (65649552..65737464)

Chromosome 15 - NC_037342.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

New function of the CD44 gene: Lipid metabolism regulation in bovine mammary epithelial cells.
Title: New function of the CD44 gene: Lipid metabolism regulation in bovine mammary epithelial cells.
CD44 knock-down in bovine and human chondrocytes results in release of bound HYAL2.
Title: CD44 knock-down in bovine and human chondrocytes results in release of bound HYAL2.
release of the CD44 intracellular domain into the cytoplasm of cells such as chondrocytes exerts a competitive or dominant-negative effect on the function of full-length CD44.
Title: Intracellular domain fragment of CD44 alters CD44 function in chondrocytes.
CD44 fragmentation, consistent with a signature pattern reported for sequential metalloproteinase/gamma-secretase cleavage of CD44, is a common metabolic feature of chondrocytes that have undergone dedifferentiation in vitro
Title: Induction of CD44 cleavage in articular chondrocytes.
The novel finding that TSP-1-induced migration is dependent on the CD44 receptor links 2 pathways thought to be disparate (ie, TSP-1 and HyA).
Title: Thrombospondin-1-induced vascular smooth muscle cell migration is dependent on the hyaluronic acid receptor CD44.
Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 and RHAMM-mediated signalling pathways involving Cdc2 and gamma-adducin.
Title: Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 and RHAMM-mediated signalling pathways involving Cdc2 and gamma-adducin.
detection of CD44 in the bovine oviductal epithelium
Title: Detection of the hyaluronan receptor CD44 in the bovine oviductal epithelium.
determined the effects of Mycobacterium-induced proliferation and apoptosis on CD25, CD44, and CD62L expression on peripheral blood T-cell subsets from M. bovis-infected cattle.
Title: Expression of L-Selectin (CD62L), CD44, and CD25 on activated bovine T cells.

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General gene information

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Markers

CD44_mf (e-PCR)
- UniSTS:510347

CD44 (e-PCR), detects polymorphism
- UniSTS:278173

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of macrophage migration inhibitory factor receptor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: CD44 antigen

Names: CD44 molecule (Indian blood group); ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; PGP-1; PGP-I; extracellular matrix receptor III; hermes antigen; homing function and Indian blood group system; hyaluronate receptor; phagocytic glycoprotein 1; phagocytic glycoprotein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174013.3 → NP_776438.2 CD44 antigen precursor

See identical proteins and their annotated locations for NP_776438.2

Status: VALIDATED

Source sequence(s)

BC119907, EV679714

UniProtKB/Swiss-Prot

Q29423

UniProtKB/TrEMBL

Q0VD03

Conserved Domains (1) summary

cd03516
Location:26 → 168

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

Range

65649552..65737464

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_059874550.1 → XP_059730533.1 CD44 antigen isoform X10

UniProtKB/TrEMBL

A0A3Q1LHV0
XM_059874551.1 → XP_059730534.1 CD44 antigen isoform X10

UniProtKB/TrEMBL

A0A3Q1LHV0
XM_005216354.2 → XP_005216411.1 CD44 antigen isoform X1

UniProtKB/TrEMBL

A0A3Q1LHV0

Related

ENSBTAP00070035936.1, ENSBTAT00070060535.1

Conserved Domains (1) summary

cd03516
Location:26 → 168

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_005216356.3 → XP_005216413.1 CD44 antigen isoform X2

UniProtKB/TrEMBL

A0A3Q1LHV0, A0A3Q1LZS6

Conserved Domains (1) summary

cd03516
Location:26 → 168

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_015474840.2 → XP_015330326.1 CD44 antigen isoform X5

UniProtKB/TrEMBL

A0A3Q1LHV0

Conserved Domains (1) summary

cd03516
Location:26 → 168

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_005216358.3 → XP_005216415.1 CD44 antigen isoform X4

UniProtKB/TrEMBL

A0A3Q1LHV0, F1MQT9

Related

ENSBTAP00070035972.1, ENSBTAT00070060573.1

Conserved Domains (1) summary

cd03516
Location:26 → 168

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_005216359.3 → XP_005216416.1 CD44 antigen isoform X7

UniProtKB/TrEMBL

F6RT51

Conserved Domains (1) summary

cd03516
Location:26 → 168

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_015474842.2 → XP_015330328.1 CD44 antigen isoform X11

Conserved Domains (1) summary

cd03516
Location:26 → 168

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_015474841.2 → XP_015330327.1 CD44 antigen isoform X6

UniProtKB/TrEMBL

A0A3Q1M161, F6RT51

Related

ENSBTAP00070035946.1, ENSBTAT00070060547.1

Conserved Domains (1) summary

cd03516
Location:26 → 168

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_024974980.2 → XP_024830748.1 CD44 antigen isoform X12

UniProtKB/TrEMBL

F6RT51

Conserved Domains (1) summary

cd03516
Location:26 → 168

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_015474843.2 → XP_015330329.1 CD44 antigen isoform X14

UniProtKB/Swiss-Prot

Q29423

Conserved Domains (1) summary

cd03516
Location:26 → 168

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_005216357.3 → XP_005216414.1 CD44 antigen isoform X3

UniProtKB/TrEMBL

A0A3Q1LHV0, A0A3Q1M0L0

Related

ENSBTAP00070035965.1, ENSBTAT00070060566.1

Conserved Domains (1) summary

cd03516
Location:26 → 168

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_005216360.3 → XP_005216417.1 CD44 antigen isoform X8

UniProtKB/TrEMBL

A0A3Q1MHE2, F6RT51

Related

ENSBTAP00070035981.1, ENSBTAT00070060581.1

Conserved Domains (1) summary

cd03516
Location:26 → 168

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_005216361.3 → XP_005216418.1 CD44 antigen isoform X9

UniProtKB/TrEMBL

F6RT51

Conserved Domains (1) summary

cd03516
Location:26 → 168

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_005216364.3 → XP_005216421.1 CD44 antigen isoform X13

UniProtKB/Swiss-Prot

Q29423

Conserved Domains (1) summary

cd03516
Location:26 → 168

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...